NPPB, natriuretic peptide B, 4879

N. diseases: 193; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation disease BEFREE Common genetic variants reported to be associated with BNP levels were not associated with a relevant risk of heart failure in our population-based cohort. 23315043 2013
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE The comparison of prognosis⁻predictivity of a single measurement of plasma NT-pro BNP in different follow-up periods in acute HF patients has been less studied. 30871208 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE TC could improve 6MWD, Qol and LVEF in patients with HF and may reduce BNP and HR. 29375390 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease CTD_human [B-type natriuretic peptide (BNP) levels and the effects of carvedilol on BNP levels in juvenile rats with right heart failure]. 19650993 2009
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE Brain natriuretic peptide (BNP) gene expression accompanies cardiac hypertrophy and heart failure. 11230322 2001
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human Brain natriuretic peptide is a predictor of anthracycline-induced cardiotoxicity. 11279304 2000
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation disease BEFREE For example, GWAS of NT-proBNP levels not only identified variants in the NNPA-NPPB locus but also substantiated data suggesting that natriuretic peptides in itself are associated with a lower risk of hypertension and HF. 29912321 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease CTD_human Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure. 24535859 2014
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human [B-type natriuretic peptide (BNP) levels and the effects of carvedilol on BNP levels in juvenile rats with right heart failure]. 19650993 2009
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease CTD_human Nesiritide: past, present, and future. 16333235 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). 16762801 2006
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human Clinical and hemodynamic effects of nesiritide (B-type natriuretic peptide) in patients with decompensated heart failure receiving beta blockers. 15860969 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease CTD_human Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure. 15732037 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure. 24535859 2014
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease RGD Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure. 1831369 1991
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Therapeutic disease CTD_human Use of natriuretic peptides for detecting cardiac dysfunction in long-term disease-free breast cancer survivors. 16101196 2005
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease LHGDN [BNP tests in the emergency department to diagnose congestive heart failure]. 17086116 2006
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation disease BEFREE By multiple linear regression analysis adjusted for age and sex, heart failure (HF) and BNP strongly associated with sST2 concentration. 29428199 2018
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE We found that thrombin-induced COX-2 expression, PGE2 release and cardiomyocyte hypertrophy markers (increase in ANF/BNP, α-actin expression and cell surface area) was attenuated by pretreatment with CORM-2 which was partially reversed by hemoglobin (Hb) or ZnPP (an inhibitor of HO-1 activity), suggesting that HO-1/CO system may be of clinical importance to ameliorate heart failure through inhibition of inflammatory responses. 26385185 2015
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE The measurements of plasma natriuretic peptides (NT-proBNP, proBNP and BNP) are used to diagnose heart failure but these are expensive to produce. 24101238 2014
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation disease LHGDN Unexplained week-to-week variation in BNP and NT-proBNP is low in chronic heart failure patients during steady state. 16829184 2007
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE We investigated serum levels of UCN1, ADM, and pro BNP in 86 consecutive patients with systolic HF [ejection fraction (EF) ≤45%] and 85 healthy controls. 25868038 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker disease BEFREE The developed LFIA for BNP could rapidly rule out HF with the naked eye, offering tremendous potential for POC test and personalized medicine. 28670119 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression disease BEFREE Echocardiography and the expression of BNP showed that rivaroxaban attenuated heart failure. 30867376 2019