Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
On top of that, cardiomyocyte areas were larger in heart tissues of MI rats with upregulation of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) gene expression, indicating cardiac hypertrophy.
|
30128816 |
2019 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Both in unadjusted and adjusted Cox-regressions, BNP-change as a continuous variable was associated with incident sudden death/myocardial infarction at 30 days (odds ratio 1.032 per each increase of 10 pg/dl, 95% confidence interval: 1.013-1.052, <i>p</i><0.001), but BNP-D1 was not.
|
29359586 |
2019 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
The focus of this review is to summarize findings on biomarkers of myocardial fibrosis (PICP and PIIINP), profibrotic mediators (TGF-beta1), extracellular matrix remodeling (MMP-9), myocardial stretch (BNP and NTpro-BNP), inflammation (interleukins, C-reactive protein and sCD40L), and myocardial necrosis (high-sensitivity troponin T), biomarkers, that can be used in clinical practice to stratify patients at risk for POAF.
|
28748762 |
2019 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Because biomarker assessment is often the first diagnostic employed in such patients, understanding biomarker differences in men vs. women may improve female morbidity and mortality rates.Some key examples of cardiac biomarker utility based on sex include contemporary use of "unisex" troponin reference intervals under-diagnosing myocardial necrosis in women; greater use of hsCRP in the setting of acute coronary syndrome (ACS) could lead to better stratification in women; and greater use of BNP with sex-specific thresholds in ACS could also lead to more timely risk stratification in women.Accurate diagnosis, appropriate risk management, and monitoring are key in the prevention and treatment of cardiovascular diseases; however, the assessment tools used must also be useful or at least assessed for utility in both sexes.
|
30223899 |
2018 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In MI+STNx groups, SIRT1 knockout led to more severe cardiac structural and functional deterioration, with higher Masson-staining score and BNP levels, and lower EF, FS, Max +dp/dt, and Max -dp/dt values; while SIRT1 overexpression had the opposite attenuating effects.
|
29566363 |
2018 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found that BRD4 protein expression was significantly increased in cardiomyocytes of MI rat model and cardiomyocytes under hypoxia, accompanied by the expression of natriuretic peptide A (NPPA) and natriuretic peptide B (NPPB).
|
29352508 |
2018 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
While solely pre-administration of Se or Tau resulted in partial amelioration in all of the measured parameters in MI rats, concomitant administration of both drugs to MI rats significantly restored contractility function by increasing LVSP and decreasing LVEDP and significantly normalized serum levels of LDH, CK-MB and BNP and restored normal cardiac architecture.
|
28699791 |
2017 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Using NOD-SCID murine model of MI and human skeletal myoblast transplantation we were able to show that SkMC administration significantly affected gene expression profile (p<0.05) (NPPB, CTGF, GATA4, SERCA2a, PLB) of the heart ventricular tissue and this change was beneficial for the heart function.
|
26457413 |
2016 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
The present study investigated the cardiac pathophysiology employing quantitative mRNA measurement of atrial and brain natriuretic peptides (ANP and BNP) in the myocardium as markers of cardiac strain, using autopsy materials consisting of acute ischemic heart disease (AIHD, n=40) with/without the pathology of apparent myocardial necrosis (n=19/21), recurrent myocardial infarction (RMI, n=19), chronic congestive heart disease (CHD, n=11) and right ventricular cardiomyopathy (RVC, n=5), as well as hemopericardium (HP, n=11) due to myocardial infarction (n=5) and aortic rupture (n=6), and acute pulmonary thromboembolism (PTE, n=5).
|
23131304 |
2012 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
BEFREE |
Atrial natriuretic peptide (ANP, also known as NPPA) and brain natriuretic peptide (BNP, also known as NPPB) have been determined as genetic factors for several diseases, including stroke and myocardial infarction, in human and rat models.
|
22400494 |
2012 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
RGD |
Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model.
|
19858735 |
2010 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
LHGDN |
Plasma B-type natriuretic peptide in diagnosing inferior myocardial infarction with right ventricular involvement.
|
18971785 |
2008 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
RGD |
Gross pathology showed around 26% infarction at 24 h. Histopathology revealed death of cardiomyocytes with blood vessel congestion at the end of 24 h, inflammatory infiltrate at 48 h, fibrotic scar by 96 h and collagen deposition by 192 h. Acute myocardial infarction biomarkers such as Cardiac Troponin T, Creatine Kinase MB and NT pro BNP were shown to be elevated by 4 h. ECG showed an ST segment elevation by 96 h. This cryoinfarction model was suitable to study changes taking place during acute myocardial infarction in humans.
|
17256064 |
2007 |
Myocardial Infarction
|
0.300 |
Biomarker
|
disease |
LHGDN |
B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction.
|
12771003 |
2003 |
Myocardial Infarction
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We conclude that 1) the proximal 408-bp region of the hBNP promoter confers cardiac-specific expression and 2) myocardial infarction activates the proximal hBNP promoter in vivo.
|
11123253 |
2001 |