NPTX2, neuronal pentraxin 2, 4885

N. diseases: 67; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.010 AlteredExpression disease BEFREE In conclusion, the present study reveals a novel regulatory mechanism of miR-96 on NPTX2 expression in RCC, and the potential of miR-96 as a RCC tumor repressor deserves further investigation. 31498486 2020
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE In conclusion, NPTX2, a molecule related to nervous system diseases, promotes CRC cell proliferation and metastasis through the activation of the Wnt/β-catenin pathway via direct interaction with FZD6. 30833544 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 AlteredExpression disease BEFREE The expression of neuronal pentraxin 2 (NPTX2) is absent in Alzheimer's disease, anxiety, and depression. 30833544 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.010 Biomarker group BEFREE In conclusion, NPTX2, a molecule related to nervous system diseases, promotes CRC cell proliferation and metastasis through the activation of the Wnt/β-catenin pathway via direct interaction with FZD6. 30833544 2019
CUI: C0162674
Disease: Chronic progressive external ophthalmoplegia
Chronic progressive external ophthalmoplegia 		0.010 Biomarker disease BEFREE It was commonly observed in subjects with chronic progressive external ophthalmoplegia (cPEO) and with primary myopathy without cPEO, but also-although less frequently-in multisystem phenotypes such as MELAS, MERFF, Kearns Sayre syndrome, NARP, MNGIE and Leigh syndrome. 30710167 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 AlteredExpression phenotype BEFREE The expression of neuronal pentraxin 2 (NPTX2) is absent in Alzheimer's disease, anxiety, and depression. 30833544 2019
CUI: C0494165
Disease: Secondary malignant neoplasm of liver
Secondary malignant neoplasm of liver 		0.010 Biomarker disease BEFREE NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6. 30833544 2019
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder 		0.010 Biomarker disease BEFREE In this cross-sectional study, rsfMRI scans were obtained from 130 older individuals (mean age = 69 years) with normal cognition (<i>N</i> = 113) and Mild Cognitive Impairment (<i>N</i> = 17); NPTX2 was measured in the same individuals in cerebrospinal fluid (CSF). 31231205 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 Biomarker disease BEFREE NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6. 30833544 2019
CUI: C0003467
Disease: Anxiety
Anxiety 		0.010 Biomarker disease BEFREE The increase in anxiety was evident in hippocampus-specific Nptx2 knockout mice, but not in an amygdala specific knockouts. 29844474 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.010 Biomarker group BEFREE The increase in anxiety was evident in hippocampus-specific Nptx2 knockout mice, but not in an amygdala specific knockouts. 29844474 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.010 AlteredExpression disease BEFREE In a preclinical period, 6-11 yr before the onset of dementia, the NDE levels of all but NPTX2 were significantly lower than those of matched controls, and levels of all proteins declined significantly with the development of dementia. 29025866 2018
CUI: C0497327
Disease: Dementia
Dementia 		0.010 AlteredExpression disease BEFREE In a preclinical period, 6-11 yr before the onset of dementia, the NDE levels of all but NPTX2 were significantly lower than those of matched controls, and levels of all proteins declined significantly with the development of dementia. 29025866 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.010 Biomarker disease BEFREE NPTX2 and cognitive dysfunction in Alzheimer's Disease. 28440221 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 Biomarker disease BEFREE Finally, we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. 26294210 2015
CUI: C0278694
Disease: Disseminated neuroblastoma
Disseminated neuroblastoma 		0.010 AlteredExpression disease BEFREE We show that, in comparison with normal tissues, NPTX2 and NPTXR are overexpressed in vivo in mouse models, as well as in human Schwannian stroma-poor, stage IV neuroblastoma. 26294210 2015
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 Biomarker disease BEFREE Finally, we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. 26294210 2015
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.010 Biomarker group BEFREE Neuronal-activity-regulated pentraxin (NARP/NPTX2/NP2) is a secreted synaptic protein that regulates the trafficking of glutamate receptors and mediates learning, memory, and drug addiction. 25466900 2015
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 Biomarker disease BEFREE Finally, we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. 26294210 2015
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 AlteredExpression group BEFREE We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccRCC primary tumors and metastases, and that it contributes to tumor cell viability and promotes cell migration through its interaction with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. 24962026 2014
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 PosttranslationalModification disease BEFREE Promoter hypermethylation of neuronal pentraxin II (NPTX2), a risky methylated gene, was confirmed by bisulfite sequencing in GBMs. 24078801 2013
CUI: C0030286
Disease: Pancreatic Diseases
Pancreatic Diseases 		0.010 Biomarker group BEFREE Here, the authors investigated the utility of methylated NPTX2 as a diagnostic marker for pancreatic cancer in pure pancreatic juice samples of patients with benign and malignant pancreatic diseases, including pancreatic cancer, intraductal papillary mucinous neoplasm or chronic pancreatitis using methylation-specific polymerase chain reaction (MSP) and quantitative MSP. 23360791 2013
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.010 PosttranslationalModification disease BEFREE There was a significant difference in NPTX2 methylation between pancreatic cancer and chronic pancreatitis (P < 0.01). 23360791 2013
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.010 PosttranslationalModification disease BEFREE Methylation of NPTX2 or PHF11 was associated with poorer prognosis in ES. 24005033 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 PosttranslationalModification disease BEFREE Promoter hypermethylation of neuronal pentraxin II (NPTX2), a risky methylated gene, was confirmed by bisulfite sequencing in GBMs. 24078801 2013