NPY1R, neuropeptide Y receptor Y1, 4886

N. diseases: 59; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.510 Biomarker group BEFREE These results indicate that GALR2/NPYY1R interactions can provide a novel integrative amygdaloid mechanism in anxiety. 24841617 2015
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.510 Therapeutic group RGD Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety. 21803058 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.510 Therapeutic group CTD_human Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety. 11440811 2001
CUI: C0028754
Disease: Obesity
Obesity
0.500 Biomarker disease CTD_human Several genes and transcripts involved in lipolysis were down-regulated, such as AKAP1, PRKAR2B, Gi and CIDEA, whereas NPY1R and CES1 were up-regulated, when comparing obese to lean subjects. 20975297 2010
CUI: C0028754
Disease: Obesity
Obesity
0.500 Biomarker disease RGD Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. 17447163 2007
CUI: C0028754
Disease: Obesity
Obesity
0.500 Biomarker disease MGD Behavioural, neural and cardiovascular adaptations in mice lacking the NPY Y1 receptor. 15652259 2005
CUI: C0028754
Disease: Obesity
Obesity
0.500 Biomarker disease MGD Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. 14525913 2004
CUI: C0028754
Disease: Obesity
Obesity
0.500 Biomarker disease MGD Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor. 11826154 2002
CUI: C0028754
Disease: Obesity
Obesity
0.500 Biomarker disease MGD Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice. 11287097 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.320 Biomarker disease BEFREE In this study, we measured the mRNA expression levels of dysbindin-1, NRG-1 and two other genes (NPY1R and GNAO1) in immortalized lymphocytes from 45 patients with schizophrenia and 45 controls using real-time quantitative reverse transcriptase-PCR. 21512575 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.320 Biomarker disease PSYGENET In this study, we measured the mRNA expression levels of dysbindin-1, NRG-1 and two other genes (NPY1R and GNAO1) in immortalized lymphocytes from 45 patients with schizophrenia and 45 controls using real-time quantitative reverse transcriptase-PCR. 21512575 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.320 Biomarker disease PSYGENET The expression of the neuropeptide Y receptor Y1 gene (NPY1R localized at 4q31.3-q32) and the human guanine nucleotide-binding regulatory protein Go-alpha (GNAO1 localized at 16q13) was significantly decreased in individuals with schizophrenia compared to unaffected family controls by microarray and real-time PCR. 14741323 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.320 Biomarker disease BEFREE The expression of the neuropeptide Y receptor Y1 gene (NPY1R localized at 4q31.3-q32) and the human guanine nucleotide-binding regulatory protein Go-alpha (GNAO1 localized at 16q13) was significantly decreased in individuals with schizophrenia compared to unaffected family controls by microarray and real-time PCR. 14741323 2004
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.310 Biomarker group PSYGENET It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication. 19566775 2009
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.310 GeneticVariation group BEFREE Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them. 19566775 2009
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.310 GeneticVariation disease BEFREE Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them. 19566775 2009
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.310 Biomarker disease PSYGENET It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication. 19566775 2009
CUI: C0033937
Disease: Psychoses, Drug
Psychoses, Drug
0.300 Biomarker disease CTD_human Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. 19566775 2009
CUI: C0033941
Disease: Psychoses, Substance-Induced
Psychoses, Substance-Induced
0.300 Biomarker disease CTD_human Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. 19566775 2009
CUI: C0236733
Disease: Amphetamine-Related Disorders
Amphetamine-Related Disorders
0.300 Biomarker group CTD_human Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. 19566775 2009
CUI: C0236804
Disease: Amphetamine Addiction
Amphetamine Addiction
0.300 Biomarker disease CTD_human Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. 19566775 2009
CUI: C0236807
Disease: Amphetamine Abuse
Amphetamine Abuse
0.300 Biomarker disease CTD_human Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. 19566775 2009
CUI: C0040460
Disease: Toothache
Toothache
0.300 Therapeutic phenotype CTD_human Neuropeptide Y Y1 receptor effects on pulpal nociceptors. 18809749 2008
CUI: C0011999
Disease: Diastematomyelia
Diastematomyelia
0.300 Biomarker disease CTD_human Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development. 17400914 2007
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects
0.300 Biomarker group CTD_human Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development. 17400914 2007