|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.
|
28710706 |
2018 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we aimed to investigate the clinicopathological aspects of a large series of follicular thyroid carcinomas (FTCs) in paediatric patients and to analyse the point mutations in codons 12, 13 and 61 of NRAS, HRAS and KRAS genes and the rearrangements of PAX8-PPARG.
|
28621837 |
2017 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
NRAS mutation was found in 17/51 (33.3%) Japanese FTCs and 4/23 (17.4%) Vietnamese FTCs.
|
27264674 |
2016 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations were detected in 2/5 FTC (PAX8/PPARγ and NRAS) and 3/6 FVPTC cases (PAX8/PPARγ).
|
26649796 |
2016 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the NRAS(Q61R) in FTAs and FTCs were significantly higher than that in NH (P=.046 and P=.001, respectively).
|
26980032 |
2016 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Total mutations found in the FNA and in the corresponding histological specimen in both series were: one PAX8/PPARG rearrangement in a follicular carcinoma (FC), four NRAS mutations [in two FCs, one papillary carcinoma and one follicular adenoma (FA)] and one HRAS mutation in one FA.
|
25487739 |
2015 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
K-RAS codon 12-13 (n = 6, 31.6 %), N-RAS codon 61 (n = 5, 26.3 %), H-RAS codon 61 (n = 4, 21.1 %), K-RAS codon 61 (n = 3, 15.8 %), and N-RAS codon 12-13 (n = 1, 5.3 %) were found in FTCs, and N-RAS codon 61 (n = 10, 45 %), K-RAS codon 12-13 (n = 5, 22.7 %), H-RAS codon 61 (n = 5, 22.7 %), K-RAS codon 61 (n = 1, 4.5 %), and N-RAS codon 12-13 (n = 1, 4.5 %) were observed in FTAs.
|
25999051 |
2015 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A total of 37 thyroid aspirates, including benign hyperplastic nodules (HBN, N = 16) and follicular thyroid carcinomas (FTC, N = 21) were analyzed for the presence of NRAS(61) and KRAS(13) mutations.
|
24866065 |
2014 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The NRAS codon 61 mutation status might be a potential prognostic factor in FTC patients.
|
24820091 |
2014 |
|
Follicular thyroid carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A similar genetic abnormality of N-ras genes at codon 61 between follicular adenoma and follicular carcinoma suggests that the mutation of N-ras at codon 61 might play a part in oncogenesis in follicular tumors.
|
7704243 |
1995 |
|
Follicular thyroid carcinoma
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Follicular thyroid carcinoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|