NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 CausalMutation disease CGI
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease HPO
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Mutations in the ras genes are key events in the process of carcinogenesis; in particular, point mutations in codon 61 of exon 2 of the N-ras gene occur frequently in cutaneous melanoma. 11886512 2001
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Mutations in codons 12, 13, and 61 of the N-ras gene are common alterations in cutaneous malignant melanoma. 12446472 2002
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE In addition, NRAS mutations were found in 2/11 (18.2%) CANs and 3/12 (25%) CMs. 15252839 2004
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease BEFREE Previous studies have shown frequent mutations in the BRAF (V-raf murine sarcoma viral oncogene homolog B1) or NRAS (neuroblastoma RAS viral [V-ras] oncogene homolog) genes in cutaneous melanoma, but the relationship between these alterations and tumor cell proliferation has not been examined in human melanoma. 16098042 2005
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Thus far, there is very limited data combining BRAF and NRAS mutation analysis to explore differences between cutaneous melanoma subtypes. 16899595 2006
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease BEFREE Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma. 18227705 2008
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease BEFREE Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis. 18205010 2008
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma. 19037234 2009
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 AlteredExpression disease BEFREE The BRAF/NRAS mutation status and expression of COX-2 and iNOS were examined to compare their prognostic value for overall survival (OS) in stage III malignant cutaneous melanoma. 19039588 2009
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 PosttranslationalModification disease BEFREE High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma. 20703244 2010
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma. 21615881 2011
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis. 21166657 2011
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE NRAS and BRAF mutations in cutaneous melanoma and the association with MC1R genotype: findings from Spanish and Austrian populations. 23096702 2013
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE When NRAS(G12D) was expressed in the melanocytes of developing embryos, it induced melanocyte proliferation and congenital melanocytic lesions reminiscent of human blue nevi but did not induce cutaneous melanoma. 23303902 2013
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma. 24749938 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Notably, common BRAF and NRAS mutations in cutaneous melanoma are associated with increased miR-21 expression. 26116372 2015
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Activating mutations in neuroblastoma RAS viral oncogene homolog (NRAS) are frequent driver events in cutaneous melanoma. 26967478 2016
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease BEFREE Only mutations confirmed via digital droplet PCR or in BRAF, KIT and NRAS, the most frequently altered cancer genes in cutaneous melanoma, were considered as positive. 28191690 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease BEFREE Few studies have focused on the transcriptional level of RAS isoforms (KRAS, NRAS, and HRAS) in cutaneous melanoma. 29349077 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE Oncogenic mutations in c-KIT, NRAS and BRAF components of the MAPK pathway have been identified in nearly 90% of cutaneous melanoma and this information has been used to develop small molecules that inhibit their activity. 29061773 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 Biomarker disease BEFREE Management strategies are proposed for presentation of suspected melanoma of the skin and the central nervous system in patients with CMN, including use of oral mitogen-activated protein kinase kinase inhibitors in NRAS-mutated tumours. 28078671 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma
0.500 GeneticVariation disease BEFREE In this work we present an intensively pigmented and well-characterized cell line derived from a highly aggressive NRAS mutated cutaneous melanoma, named MUG-Mel2. 28522871 2017