NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0432333
Disease: Abnormal dermatoglyphic pattern
Abnormal dermatoglyphic pattern
0.100 Biomarker disease HPO
CUI: C4023397
Disease: Abnormal hair quantity
Abnormal hair quantity
0.100 Biomarker disease HPO
CUI: C0855740
Disease: Abnormal platelet function
Abnormal platelet function
0.100 Biomarker phenotype HPO
CUI: C1846821
Disease: Abnormality of coagulation
Abnormality of coagulation
0.100 Biomarker phenotype HPO
CUI: C4023551
Disease: Abnormality of dental color
Abnormality of dental color
0.100 Biomarker phenotype HPO
CUI: C2674737
Disease: Abnormality of finger
Abnormality of finger
0.100 Biomarker phenotype HPO
Abnormality of metabolism/homeostasis
0.100 Biomarker phenotype HPO
CUI: C3164374
Disease: Abnormality of pulmonary valve
Abnormality of pulmonary valve
0.100 Biomarker disease HPO
CUI: C4025749
Disease: Abnormality of the spleen
Abnormality of the spleen
0.100 Biomarker disease HPO
CUI: C2674738
Disease: Abnormality of toe
Abnormality of toe
0.100 Biomarker group HPO
CUI: C4025846
Disease: Abnormality of vision
Abnormality of vision
0.100 Biomarker disease HPO
CUI: C0158486
Disease: Acquired genu recurvatum
Acquired genu recurvatum
0.100 Biomarker phenotype HPO
CUI: C0600033
Disease: Acquired Kyphoscoliosis
Acquired Kyphoscoliosis
0.100 Biomarker disease HPO
CUI: C0151860
Disease: Acquired porencephaly
Acquired porencephaly
0.100 Biomarker disease HPO
Acral Lentiginous Malignant Melanoma
0.020 Biomarker disease BEFREE Novel studies investigating the biologic characteristics of acral MM reported variable results: the overall mutational rates ranged respectively between 8.5% and 23% for KIT, between 3.6% and 33.3% for BRAF and between 3% and 47% for NRAS in ALMs. 29512974 2019
Acral Lentiginous Malignant Melanoma
0.020 GeneticVariation disease BEFREE TERT promoter mutations were found in 9.3% of the cases, BRAF in 10.3%, NRAS in 7.5%, KIT in 20.7%, and PDGFRA in 14.8% of ALM. 26709572 2016
CUI: C0001206
Disease: Acromegaly
Acromegaly
0.010 GeneticVariation disease BEFREE Despite the relation of BRAF V600E and NRAS codon 61 mutations with aggresive histopathologic features, their impact on tumor prognosis remains to be defined in acromegaly in further studies. 26575115 2016
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia
0.020 GeneticVariation disease BEFREE These three MDS patients with p53 gene mutations and an MDS-derived erythroleukemia cell line that we had previously reported to carry a p53 gene mutation showed no N-ras gene mutations, suggesting heterogeneity in the oncogenic mechanism of MDS. 8499637 1993
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia
0.020 Biomarker disease BEFREE We show here, for the first time, that both N-RAS and H-RAS can impair erythroid differentiation of erythroleukaemia cells induced with hexamethylene bisacetamide. 9301684 1997
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.060 Biomarker disease BEFREE A trend was found between the overexpression of the N-ras gene and the acute leukemias: all 10 acute leukemias exhibited overexpression of the N-ras gene, while only two of the CML cases, both in blastic crisis, showed elevated levels of the N-ras gene. 8948029 1996
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.060 GeneticVariation disease BEFREE Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. 25833960 2015
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.060 AlteredExpression disease BEFREE Our observations indicate that in vivo selection assays detect transforming genes including ras oncogenes at high frequency, and that activated N-ras genes are frequently detected in human acute leukemias. 3632661 1987
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.060 GeneticVariation disease BEFREE Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia. 26222068 2015
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.060 GeneticVariation disease BEFREE K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements. 16404744 2006
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.060 GeneticVariation disease BEFREE The authors analyzed MIN in de novo acute leukemia and its association with expression of the human MSH3 (hMSH3) gene and point mutations of the N-ras gene. 9690540 1998