NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: Central nervous system melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332888
Disease: Central nervous system melanoma
Central nervous system melanoma 		0.040 GeneticVariation disease BEFREE In support of this model, two pediatric cases of NRAS-mutant primary melanoma of the CNS are identified. 23580282 2013
CUI: C1332888
Disease: Central nervous system melanoma
Central nervous system melanoma 		0.040 GeneticVariation disease BEFREE We show that the acquisition of NRAS mutations in melanocytes during embryogenesis is a risk factor for early-onset melanoma of the CNS. 23303902 2013
CUI: C1332888
Disease: Central nervous system melanoma
Central nervous system melanoma 		0.040 GeneticVariation disease BEFREE Trametinib is the first therapy to show any objective or measurable effect in NRAS-mutated primary CNS melanoma, with few side effects in this small series. 28253523 2017
CUI: C1332888
Disease: Central nervous system melanoma
Central nervous system melanoma 		0.040 GeneticVariation disease BEFREE Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi. 29077579 2018