NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.500 Biomarker disease BEFREE MEK1 is required for the development of NRAS-driven leukemia. 27741509 2016
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis. 27698462 2016
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE In a patient with a BRAF(V600K)-mutant melanoma responding to vemurafenib, we observed accelerated progression of a previously unrecognized NRAS-mutant leukemia. 24589925 2014
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Characterization of a patient with concurrent BRAF-mutant melanoma and NRAS-mutant leukemia treated intermittently with combined BRAF and MEK inhibition provides new insights into the potential clinical and molecular effects of this therapeutic strategy. 24795008 2014
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Analysis of the gene-expression patterns of leukemic subpopulations revealed that the NRAS(G12V)-mediated leukemia self-renewal signature is preferentially expressed in the leukemia stem cell-enriched subpopulation. 25316678 2014
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Both monoallelic and biallelic oncogenic NRAS mutations are identified in human leukemias, suggesting a dose-dependent role of oncogenic NRAS in leukemogenesis. 21586752 2011
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Injecting Mx1-Cre, LSL-Nras(G12D) mice with the MOL4070LTR retrovirus causes acute myeloid leukemia that faithfully recapitulates many aspects of human NRAS-associated leukemias, including cooperation with deregulated Evi1 expression. 21163920 2011
CUI: C0023418
Disease: leukemia
leukemia
0.500 Biomarker disease BEFREE We compared the frequency of FLT3-length mutations (FLT3-LM), FLT3-TKD, MLL-partial tandem duplications (MLL-PTD), NRAS, and KITD816 in 381 patients with MDS refractory anemia with excess blasts [RAEB] n=49; with ringed sideroblasts [RARS] n=310; chronic monomyelocytic leukemia [CMML] n=22) and in 4130 patients with AML (de novo: n=3139; secondary AML [s-AML] following MDS: n=397; therapy-related [t-AML]: n=233; relapsed: n=361). 17550846 2007
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE In contrast, other activating mutations like FLT3 and NRAS mutations were very rarely detected in AML1-rearranged leukemia. 16254134 2006
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Genomic analyses failed to detect N-ras gene mutations in any of the 35 leukemias. 11369625 2001
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE The authors conclude that N-RAS mutations are not an early event preceding transformation of AA or AA/PNH to leukemia. 10627475 2000
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Therefore, we used single-strand conformation polymorphism analysis and an allele-specific restriction enzyme assay to investigate the frequency of KRAS and NRAS mutations in 32 pediatric leukemias with translocation of the MLL gene. 9523205 1998
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE From 5% to 20% of patients with agnogenic myeloid metaplasia (AMM) will evolve into a terminal leukemic phase; N-RAS gene mutations are the most common gene abnormalities detected in patients with leukemia. 9680115 1998
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE The mutations of the N-ras gene were detected only in two cases with MDS-derived leukemia. 9177441 1997
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE Since no NRAS mutations were detected among the t(8;21) samples and only 1 was found in the inv(16) group, we conclude that acute myeloid leukaemias with t(8;21) or inv(16) generally arise and progress without the involvement of NRAS mutations. 8599996 1996
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE These findings indicate that the N-ras mutations may not always be characterized simply by an accumulative process and that the activated N-ras gene alone is not sufficient to cause leukemia. 8514604 1993
CUI: C0023418
Disease: leukemia
leukemia
0.500 Biomarker disease BEFREE Because the INS gene, which was also translocated, is probably located proximal to HRAS1 on chromosome 11p, it is unlikely that HRAS1 was near the chromosome 11 breakpoint or involved in this leukaemia. 2713271 1989
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease BEFREE These observations suggest that the chromosomal abnormality may precede activation of the N-ras gene in these patients, and that both the chromosomal abnormality and the activated N-ras oncogene contribute to the development of leukemia. 3275473 1988
CUI: C0023418
Disease: leukemia
leukemia
0.500 AlteredExpression disease BEFREE Our observation of the mutation at codon 13 in leukaemic cell DNAs from all three cases suggests that activation of the N-ras gene is important in the development of leukaemia in some MDS cases. 3295562 1987
CUI: C0023418
Disease: leukemia
leukemia
0.500 GeneticVariation disease UNIPROT
CUI: C0023418
Disease: leukemia
leukemia
0.500 Biomarker disease HPO