NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027831
Disease: Neurofibromatosis 1
Neurofibromatosis 1
0.050 GeneticVariation disease BEFREE More recently, much attention has focused on the role of NF1 and neurofibromin in melanoma as mutations in NF1 have been found to constitute 1 of the 4 distinct genomic categories of melanoma, with the other 3 comprising BRAF, NRAS, and "triple-wild-type" subtypes. 27941538 2017
CUI: C0027831
Disease: Neurofibromatosis 1
Neurofibromatosis 1
0.050 AlteredExpression disease BEFREE Previously, we have shown that N-Ras is constitutively activated in cell lines derived from independent MPNSTs from NF1 patients. 20680410 2010
CUI: C0027831
Disease: Neurofibromatosis 1
Neurofibromatosis 1
0.050 Biomarker disease BEFREE Affinity purification showed N-Ras to be the predominant activated isoform of Ras in two independent neurofibrosarcoma cell lines from NF1 patients (lines ST88-14 and NF90-8). 16239399 2006
CUI: C0027831
Disease: Neurofibromatosis 1
Neurofibromatosis 1
0.050 GeneticVariation disease BEFREE We investigated the mutational status of the N-ras gene and the FLR exon of codons 1371-1423 of the open reading frame of the full-length NF1 cDNA, which has a strong homology with the mammalian ras GTPase-activating protein (GAP), especially for a stretch of three consecutive amino acids (F, L, R), by single-strand conformation polymorphism analysis and direct sequencing in samples from patients with AML. 8528106 1995
CUI: C0027831
Disease: Neurofibromatosis 1
Neurofibromatosis 1
0.050 GeneticVariation disease BEFREE Three of 39 (7.7%) cases showed mobility shifts in the ras family gene but no point mutations in NF1 and N-ras genes could be detected. 8533197 1995