NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036631
Disease: Seminoma
Seminoma
0.050 Biomarker disease BEFREE The most common genomic alterations found in TGCTs include gains in chromosome 12p and mutations in KIT, KRAS, and NRAS, particularly in seminomas. 31045925 2019
CUI: C0036631
Disease: Seminoma
Seminoma
0.050 GeneticVariation disease BEFREE The number of expressed CT genes was significantly higher in seminomas (P = 3.48 × 10<sup>-13</sup> ) which were characterized by frequent mutations in driver genes (KIT, KRAS and NRAS). 31070303 2019
CUI: C0036631
Disease: Seminoma
Seminoma
0.050 GeneticVariation disease BEFREE We investigated K-RAS and N-RAS mutations in seminoma and non-seminoma TGCT patients. 28426398 2017
CUI: C0036631
Disease: Seminoma
Seminoma
0.050 GeneticVariation disease BEFREE Using the polymerase chain reaction (PCR) and allele specific oligonucleotide hybridization (ASO), mutations were found in five SE (three in NRAS and two in KRAS, all codon 12), and in one NS (KRAS, codon 12). 7535083 1995
CUI: C0036631
Disease: Seminoma
Seminoma
0.050 GeneticVariation disease BEFREE Mutations were detected in 40% of the seminomas at codons 12 or 61 of either the Ki-ras or the N-ras gene. 2682461 1989