NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 477; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041409
Disease: Turner Syndrome, Male
Turner Syndrome, Male
0.440 Biomarker disease BEFREE While the underlying pathophysiologic mechanism of PIG is unclear, we suggest that the mitogen-activated protein kinase signal transduction pathway members (PTPN11, KRAS, SOS1, RAF1, SHOC2, NRAS) involved in cellular growth factor signaling, which are affected in NS, can provide clues. 24039098 2014
CUI: C0041409
Disease: Turner Syndrome, Male
Turner Syndrome, Male
0.440 GeneticVariation disease BEFREE RASopathies (Noonan syndrome (NS) and Noonan-related syndromes) are neurodevelopmental syndromes resulting from germline mutations in genes that participate in the rat sarcoma/mitogen-activated protein kinases (RAS/MAPK) pathway (PTPN11, SOS1, RAF, KRAS or NRAS, and SHOC2). 23786871 2014
CUI: C0041409
Disease: Turner Syndrome, Male
Turner Syndrome, Male
0.440 GeneticVariation disease BEFREE In conclusion, mutations in NRAS from individuals with Noonan syndrome activated N-Ras signaling and induced developmental defects in zebrafish embryos, indicating that activating mutations in NRAS cause Noonan syndrome. 21263000 2011
CUI: C0041409
Disease: Turner Syndrome, Male
Turner Syndrome, Male
0.440 Biomarker disease CTD_human A restricted spectrum of NRAS mutations causes Noonan syndrome. 19966803 2010
CUI: C0041409
Disease: Turner Syndrome, Male
Turner Syndrome, Male
0.440 GeneticVariation disease BEFREE A restricted spectrum of NRAS mutations causes Noonan syndrome. 19966803 2010
CUI: C0041409
Disease: Turner Syndrome, Male
Turner Syndrome, Male
0.440 CausalMutation disease CLINVAR Noonan Syndrome 20301303 1993