|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings underline the likely importance of NRAS gene rs2273267 A>T in the risk of neuroblastoma.
|
31759987 |
2020 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Correction: Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.
|
28107499 |
2019 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations of BRAF (B-type Raf kinase) were detected in 23 and mutation of NRAS (Neuroblastoma RAS Viral Oncogene Homolog) in 2 papillary thyroid cancers.
|
28493027 |
2017 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As well as MYCN amplification, activating point mutations of ALK and NRAS are associated with high-risk and relapsing neuroblastoma.
|
28602975 |
2017 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Likewise, sgRNAs for NRAS and MAP2K1 (MEK1), a downstream kinase of mutant NRAS, were identified among the top hits in the NRAS-mutant neuroblastoma cell line CHP-212.
|
27613601 |
2016 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRAF = v-raf murine sarcoma viral oncogene homolog B1 FLUS = follicular lesion of undetermined significance FNAB = fine-needle aspiration biopsy FTC = follicular thyroid carcinoma HRAS = homologous to the oncogene from the Harvey rat sarcoma virus KRAS = homologous to the oncogene from the Kirsten rat sarcoma virus NRAS = first isolated from a human neuroblastoma/neuroblastoma RAS = viral oncogene homolog PAX8 = paired box 8 PCR = polymerase chain reaction PPAR-gamma = peroxisome proliferator-activated receptor gamma PTC = papillary thyroid carcinoma RAS = rat sarcoma RET = rearranged during transfection tyrosine-kinase proto-oncogene SM = somatic mutation SNP = single-nucleotide polymorphism.
|
27214302 |
2016 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three KRAS [Kirsten rat sarcoma viral oncogene homolog] mutations, 1 BRAF (v-Raf murine sarcoma viral oncogene homolog B1) mutation, and 1 NRAS (neuroblastoma RAS viral oncogene homolog) mutation were identified in the remaining lung adenocarcinomas.
|
26682952 |
2016 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Attempts to directly block the mutant neuroblastoma rat sarcoma oncogene (NRAS) protein, a driving mutation in many cancer types, have been unsuccessful.
|
25504439 |
2015 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activating mutations in the neuroblastoma rat sarcoma viral oncogene homolog (NRAS) gene are common genetic events in malignant melanoma being found in 15-25% of cases.
|
23431193 |
2013 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore the mutation frequencies of BRAF(V600E) (V-raf murine sarcoma virus oncogene homolog B1) and NRAS (neuroblastoma ras viral oncogene homolog) codon 61 in CMNs of Chinese, we selected 55 paraffin-embedded tissue blocks, including 37 cases of medium CMNs (1.5-20cm) and 18 cases of giant CMNs (>20 cm).
|
21430505 |
2011 |
|
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the incidence of B-raf, Kirsten-ras (K-ras) and Neuroblastoma-ras (N-ras) gene mutations in esophageal squamous cell carcinoma (ESCC) in the Greek population.
|
18592405 |
2008 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, Ras family members (Hras1, Kras2 and Nras) and the downstream effectors Pik3ca and Braf, were sequenced from twenty-five neuroblastomas arising in neuroblastoma-prone transgenic mice.
|
16822308 |
2006 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of neuroblastoma cells with an inhibitor of the farnesyl-protein-transferase (FPTase) inactivated H-ras protein completely and N-ras protein by more than 50 %.
|
11807663 |
2001 |