NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: Malignant transformation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.050 Biomarker phenotype BEFREE Finally, we developed ZT-12-037-01 (1a) as a specific STK19-targeted inhibitor and showed that it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 30712867 2019
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.050 GeneticVariation phenotype BEFREE In melanoma, activation of the mitogen-activated protein kinase (MAPK) pathway driven by mutant BRAF or NRAS is a primary cause of malignant transformation. 27270434 2017
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.050 GeneticVariation phenotype BEFREE In this series the presence of a BRAF- or NRAS mutation in a nevus was not associated with the risk of malignant transformation. 23861977 2013
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.050 PosttranslationalModification phenotype BEFREE Our findings suggest that overexpression of N-Ras gene plays an important role in malignant transformation of 16HBE cells by anti-BPDE. 18567617 2008
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.050 Biomarker phenotype BEFREE However, immortalization per se was shown not to guarantee 'co-operation' with an activated N-ras gene to give malignant transformation. 2208593 1990