Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Cytogenetically normal acute myeloid leukemia
0.040 GeneticVariation disease BEFREE In contrast to reports of noncanonical RAS mutations in other cancers, including some leukemia subtypes, we only observed K- and N-RAS mutations in codons 12, 13, or 61 in CN-AML samples. 24737308 2014
Cytogenetically normal acute myeloid leukemia
0.040 GeneticVariation disease BEFREE To integrate available clinical and molecular information for cytogenetically normal acute myeloid leukemia (CN-AML) patients into one risk score, 275 CN-AML patients from multicenter treatment trials AML SHG Hannover 0199 and 0295 and 131 patients from HOVON/SAKK protocols as external controls were evaluated for mutations/polymorphisms in NPM1, FLT3, CEBPA, MLL, NRAS, IDH1/2, and WT1. 21372155 2011
Cytogenetically normal acute myeloid leukemia
0.040 Biomarker disease BEFREE Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein alpha gene (CEPBA), the myeloid-lymphoid or mixed-lineage leukemia gene (MLL), and the neuroblastoma RAS viral oncogene homolog (NRAS). 18450602 2008
Cytogenetically normal acute myeloid leukemia
0.040 GeneticVariation disease BEFREE Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype. 15674343 2005