NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4727838
Disease: Advanced Melanoma
Advanced Melanoma
0.060 GeneticVariation disease BEFREE Nevertheless, binimetinib represents another promising treatment option for advanced melanoma and the first molecularly targeted therapy for the NRAS-mutant population. 28851243 2017
CUI: C4727838
Disease: Advanced Melanoma
Advanced Melanoma
0.060 GeneticVariation disease BEFREE In addition, immune-based therapies have shown increasing activity in advanced melanoma and may be particularly effective in those with NRAS mutations. 25796376 2015
CUI: C4727838
Disease: Advanced Melanoma
Advanced Melanoma
0.060 GeneticVariation disease BEFREE This retrospective study suggests that NRAS mutations in advanced melanoma correlate with increased benefit from immune-based therapies compared with other genetic subtypes. 25736262 2015
CUI: C4727838
Disease: Advanced Melanoma
Advanced Melanoma
0.060 GeneticVariation disease BEFREE In our open-label, non-randomised, phase 2 study, we assigned patients with NRAS-mutated or BRAF-mutated advanced melanoma to one of three treatment arms on the basis of mutation status. 23414587 2013
CUI: C4727838
Disease: Advanced Melanoma
Advanced Melanoma
0.060 GeneticVariation disease BEFREE Genomic DNA from a total of 749 tumor samples (451 primary tumors and 298 metastases) in 513 consecutively-collected patients with advanced melanoma (AJCC stages III and IV) was screened for mutations in exon 15 of BRAF gene and, at lower extension (354/513; 69%), in the entire coding DNA of NRAS gene by automated direct sequencing. 23987572 2013
CUI: C4727838
Disease: Advanced Melanoma
Advanced Melanoma
0.060 GeneticVariation disease BEFREE Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma. 22130161 2012