|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For example, ret and trk genes were found to be activated by gene rearrangements in human papillary thyroid carcinomas.
|
1486840 |
1992 |
|
Papillary thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since both PTC, a novel rearranged form of RET, and TRK display a tyrosine protein kinase activity, it is proposed that the activation of this class of oncogenes is specifically involved in the pathogenesis of papillary thyroid cancer.
|
2594368 |
1989 |
|
Papillary thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we have analyzed by different molecular approaches, including Southern blotting, DNA transfection assay on NIH-3T3 cells, and reverse transcription-PCR analysis, six papillary carcinomas from children living in the region of Belarus at the time of the Chernobyl nuclear accident to identify tumor-specific gene rearrangements of the proto-oncogenes RET and TRK, previously found activated in a tumor type-specific manner in papillary thyroid carcinoma.
|
7585643 |
1995 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas.
|
7590742 |
1995 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results show that, in papillary thyroid carcinoma, the frequency of RET and NTRK1 activation is significantly higher in the group of patients aged 4-30 years, thas supporting the concept that age could be contributing to this thyroid specific carcinogenic process.
|
8626874 |
1996 |
|
Papillary thyroid carcinoma
|
0.400 |
FusionGene
|
disease |
ORPHANET |
The TFG sequence is fused to the 3' end of NTRK1, generating the TRK-T3 fusion transcript found in papillary thyroid carcinoma.
|
9169129 |
1997 |
|
Papillary thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The TFG sequence is fused to the 3' end of NTRK1, generating the TRK-T3 fusion transcript found in papillary thyroid carcinoma.
|
9169129 |
1997 |
|
Papillary thyroid carcinoma
|
0.400 |
FusionGene
|
disease |
ORPHANET |
The NTRK1 gene in the q arm of chromosome 1 encodes one of the receptors for the nerve growth factor and is frequently activated as an oncogene in papillary thyroid carcinomas.
|
9172002 |
1997 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The NTRK1 gene in the q arm of chromosome 1 encodes one of the receptors for the nerve growth factor and is frequently activated as an oncogene in papillary thyroid carcinomas.
|
9172002 |
1997 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident.
|
10074915 |
1999 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the RET and TRK proto-oncogenes, which generate fusion oncogenes, are frequent in papillary thyroid carcinomas in Caucasian populations.
|
10083732 |
1999 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TPM3 gene has been previously found in papillary thyroid carcinomas as a fusion partner with the TRK kinase gene.
|
10216106 |
1999 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because of similarities in involvement of the two tyrosine kinases RET (rearranged during transfection) and NTRK1 in the pathogenesis of PTC, the obvious parallels between RET and NTRK1 and between PTC and medullary thyroid carcinoma (MTC), NTRK1 seemed to be an excellent candidate gene to play a role in the genesis of MTC.
|
10443680 |
1999 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results concerning the radiation-associated tumours showed that only rearrangements between NTRK1 and TPM3 genes (TRK oncogene) were detected in 2/14 papillary carcinomas and in one lymph-node metastasis of one of these papillary thyroid carcinomas.
|
10646882 |
2000 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A high prevalence of RET gene rearrangements (62.3%) with a significant predominance of ELE1/RET (PTC3) over H4/RET (PTC1) rearrangements was found in PTCs of the first post-Chernobyl decade.NTRK1 rearrangements were rare (3.3%).
|
10741739 |
2000 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The high incidence of yet uncharacterized NTRK1 hybrid mRNAs in our patient cohort leads to the speculation that activating chromosomal rearrangements of several tyrosine kinase receptors may be a common feature of PTCs and that the expression of distinct chimeras may potentially be of prognostic significance.
|
11114633 |
2000 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages.
|
11165748 |
2001 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Wide differences in the frequency (0-10.9%) of the NTRK1 rearrangement in PTCs have been reported in different populations.
|
11216646 |
2000 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thyroid papillary cancers (PTCs) are associated with activating mutations of genes coding for RET or TRK tyrosine kinase receptors, as well as of RAS genes.
|
12670889 |
2003 |
|
Papillary thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.
|
15273715 |
2004 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Papillary thyroid carcinomas are marked by a high frequency of chromosome rearrangements involving the RET and NTRK1 tyrosine kinase receptor genes and producing RET and TRK oncogenes.
|
15805251 |
2005 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Somatic rearrangement of the tyrosine kinase receptor RET is restricted to papillary thyroid carcinoma (PTC).
|
15876154 |
2005 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results, together with data from our previous studies on RAS, RET rearrangements and NTRK1 rearrangements in the same tumours, were compared to determine their individual significance in the pathogenesis of PTCs in Taiwan.
|
16181240 |
2005 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, several gene products with unknown functions were demonstrated in PTCs bearing RET or NTRK1 hybrids versus rearrangement-negative PTCs, including a homologue of the Ig kappa light chain constant region.
|
16256137 |
2006 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first one in which the frequency of NTRK1 rearrangements in PTC was reported for the Polish population.
|
16483615 |
2006 |