|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Trk-A, p75NRT, and GRP78 overexpression are favorable prognostic factors in pediatric neuroblastoma, whereas Trk-B is associated with a poorer prognosis in these tumors.
|
19386345 |
2009 |
|
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NTRK1 c.1810C>T polymorphism appears to be a new independent prognostic factor of poor outcome in neuroblastoma, especially in children under 18 months of age with no MYCN amplification.
|
20003389 |
2009 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
trk A gene expression in neuroblastoma. The clinical significance of an immunohistochemical study.
|
8625212 |
1995 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A neuroblastoma is a common pediatric tumor derived from the neural crest, and the majority of favorable neuroblastomas express a high level of TRK-A mRNA.
|
8264643 |
1994 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A total of 108 tumours were classified as neuroblastoma or ganglioneuroblastoma; 74 expressed TRKA protein, which strongly correlated with low stage, absence of N-MYC amplification, age (<1 year), CD44 expression and favourable clinical outcome.
|
9099963 |
1997 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expression.
|
16618748 |
2006 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma.
|
15867224 |
2005 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By directly connecting MYCN to the repression of TRKA and p75NTR, our findings establish a key pathway of clinical pathogenicity and aggressiveness in neuroblastoma.
|
21123453 |
2011 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these results indicate that EZH2 plays important roles in preventing the differentiation of NB cells and also that EZH2-related NTRK1 transcriptional regulation may be the key pathway for NB cell differentiation.
|
29507419 |
2018 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with this result, ZAR1-depleted NB cells showed well-differentiated phenotypes with elongated neurites and upregulated expression of TRKA and RET, which are markers for differentiated NB.
|
28791558 |
2017 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Correlation of MYCN amplification, Trk-A and CD44 expression with clinical stage in 250 patients with neuroblastoma.
|
9516861 |
1997 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of TrkA protein expression by miRNA‑92a promotes the proliferation and migration of human neuroblastoma cells.
|
24839961 |
2014 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation.
|
26535632 |
2015 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Entrectinib's activity against both ALK and TRK proteins suggests a possible role in NB treatment, and it is currently under investigation in both pediatric and adult oncology patients.
|
30425456 |
2018 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome.
|
23047593 |
2012 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression level of trkA tyrosine kinase receptor for nerve growth factor is a major prognostic determinant of neuroblastoma, suggesting that defective trkA-mediated signaling is responsible for the tumorigenesis of this childhood malignancy.
|
10462038 |
1999 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma.
|
17973327 |
2008 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of Trk receptors is an important prognostic factor in neuroblastoma (NB) and other cancers.
|
19363525 |
2009 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells.
|
23400852 |
2013 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of mRNA for the trk protooncogene, encoding a tyrosine kinase receptor essential for functional NGF signal transduction, and mRNA for the low affinity NGF receptor (LNGFR) was examined in 45 neuroblastomas and 3 benign ganglioneuromas using Northern blot analysis.
|
8481906 |
1993 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression of the high-affinity nerve growth factor (NGF) TrkA receptor in NB is correlated with good prognosis, while MYCN amplification is associated with advanced stages of disease.
|
16989911 |
2006 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, MIZ-1 expression was positively correlated with the expression of favorable neuroblastoma genes (EFNB2, EFNB3, EPHB6, and NTRK1) in the human neuroblastoma xenograft therapeutic models.
|
17947461 |
2007 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study.
|
21728718 |
2011 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we used the SH-SY5Y human neuroblastoma cell line ectopically expressing either TrkA or TrkB as a model system to analyze the impact of Trk receptor expression on NHEJ-mediated DSB repair.
|
18678285 |
2008 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of a novel tyrosine kinase receptor-like molecule in neuroblastomas.
|
1281989 |
1992 |