Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease BEFREE Neuregulin-1 (NRG1) signaling through its tyrosine kinase receptor ErbB4 is essential for the normal development of the nervous system and has been linked to neuropsychiatric disorders such as schizophrenia. 29464684 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 GeneticVariation disease BEFREE Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction. 28727685 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 GeneticVariation disease BEFREE We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups. 21317683 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease BEFREE Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+) and glutamic acid decarboxylase (GAD67) mRNA levels have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. 21223646 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 GeneticVariation disease BEFREE Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia. 19435634 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease BEFREE Using a quantitative RNA-PCR approach tyrosine kinase receptor (trk) C mRNA levels were determined in brain material from the frontal cortex (BA10), temporal cortex (BA20) and cerebellum of control specimen and patients with schizophrenia, bipolar disorder or non-psychotic depression (15 subjects each). 9865928 1998