Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor. 31660632 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression. 30741614 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression. 30931847 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before. 29550391 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 PosttranslationalModification disease BEFREE Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local ERK42/44 phosphorylation and was sufficient to induce habit-based and depression-like behaviors. 29186135 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE In this study, we test whether NTRK2 allele variants are associated with mood disorders or depressive disorders in patients with TLE. 28550723 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Several nominally significant gene-based associations were detected, but only DICER1 associated with suicidal behavior in both samples, while only the associations of NTRK2 in the depression sample reached family wise and experiment wise significance. 26921221 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET We report that BDNF and selective tyrosine kinase receptor B (TrkB) agonist 7,8-dihydroxyflavone (DHF) activated the TrkB receptor to facilitate two forms of eCB-mediated synaptic depression, depolarization-induced suppression of inhibition (DSI), and long-term depression (I-LTD) of IPSCs in ventral tegmental area dopamine neurons in mouse midbrain slices. 25762688 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Polymorphisms of the brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD), and its receptor, neurotrophic tyrosine kinase receptor B (TrkB), has been associated with depression. 26641254 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum. 22609366 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum. 22609366 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE We investigated the association of nine polymorphisms throughout the CREB1-BDNF-NTRK2 pathway with lifetime depression, rumination, current depression severity, negative life events, and sad face emotion processing in a three-level design. 21215389 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET Genetic variation associated with reduced function in the CREB1-BDNF-NTRK2 pathway has multiple, sometimes opposing, influences on risk mechanisms of depression, but almost all the SNPs studied amplified the effect of childhood adversity. 21215389 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET This study examines the main effects of single loci and multilocus interactions to test the hypothesis that the BDNF and NTRK2 genes may contribute to the etiology of geriatric depression independently and/or through complex interactions. 20014955 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner. 20014955 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease PSYGENET After controlling for age, gender and baseline 21-item Hamilton Depression Rating Scale (HAM-D21) score, as well as correcting for multiple testing, the relative reduction of HAM-D21 score remained significantly associated with two NTRK2-coding SNPs (rs2289657 and rs56142442) and the haplotype CAG at rs2289658 (splice site), rs2289657 and rs2289656. 19844206 2009