Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor.
|
31660632 |
2020 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.
|
30741614 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression.
|
30931847 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before.
|
29550391 |
2018 |
Depressive disorder
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local ERK42/44 phosphorylation and was sufficient to induce habit-based and depression-like behaviors.
|
29186135 |
2017 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we test whether NTRK2 allele variants are associated with mood disorders or depressive disorders in patients with TLE.
|
28550723 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several nominally significant gene-based associations were detected, but only DICER1 associated with suicidal behavior in both samples, while only the associations of NTRK2 in the depression sample reached family wise and experiment wise significance.
|
26921221 |
2016 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We report that BDNF and selective tyrosine kinase receptor B (TrkB) agonist 7,8-dihydroxyflavone (DHF) activated the TrkB receptor to facilitate two forms of eCB-mediated synaptic depression, depolarization-induced suppression of inhibition (DSI), and long-term depression (I-LTD) of IPSCs in ventral tegmental area dopamine neurons in mouse midbrain slices.
|
25762688 |
2015 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD), and its receptor, neurotrophic tyrosine kinase receptor B (TrkB), has been associated with depression.
|
26641254 |
2015 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum.
|
22609366 |
2012 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum.
|
22609366 |
2012 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of nine polymorphisms throughout the CREB1-BDNF-NTRK2 pathway with lifetime depression, rumination, current depression severity, negative life events, and sad face emotion processing in a three-level design.
|
21215389 |
2011 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genetic variation associated with reduced function in the CREB1-BDNF-NTRK2 pathway has multiple, sometimes opposing, influences on risk mechanisms of depression, but almost all the SNPs studied amplified the effect of childhood adversity.
|
21215389 |
2011 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
This study examines the main effects of single loci and multilocus interactions to test the hypothesis that the BDNF and NTRK2 genes may contribute to the etiology of geriatric depression independently and/or through complex interactions.
|
20014955 |
2009 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.
|
20014955 |
2009 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
After controlling for age, gender and baseline 21-item Hamilton Depression Rating Scale (HAM-D21) score, as well as correcting for multiple testing, the relative reduction of HAM-D21 score remained significantly associated with two NTRK2-coding SNPs (rs2289657 and rs56142442) and the haplotype CAG at rs2289658 (splice site), rs2289657 and rs2289656.
|
19844206 |
2009 |