Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease BEFREE De-regulated brain-derived neurotrophic factor (BDNF), i.e., its signalling through the tropomyosin receptor kinase B (TrkB) receptor, is a major feature of schizophrenia. 28241130 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease BEFREE In this study, we investigated the role of genes related to the hypothalamic-pituitary-adrenal axis (FKBP5 and NR3C1) and neurotrophic factors (BDNF and NTRK2) in clinical response to clozapine in 591 schizophrenia patients. 25751398 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease BEFREE Increased truncated TrkB receptors may contribute to reduced overall BDNF/tyrosine receptor kinase B (TrkB) signaling and lead to reduced neuronal plasticity in the DLPFC in schizophrenia suggesting that therapies aimed at ameliorating neurotrophin deficits may need to consider blocking excessive truncated TrkB function. 21795612 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease PSYGENET Our findings implied that single polymorphism of rs6265 rs1387923, rs2769605, and rs1565445 in BDNF and NTRK2 were not associated with the development of paranoid schizophrenia in a Han population, however, the interaction of BDNF and NTRK2 genes polymorphisms (BDNF-rs6265, NTRK2-rs1387923 and NTRK2-rs2769605) may be involved in the susceptibility to paranoid schizophrenia. 24069289 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease LHGDN Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia. 18253057 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease BEFREE Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia. 18187310 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 GeneticVariation disease BEFREE Genetic analysis of the TrkB gene and schizophrenia in the Japanese population: Juntendo University Schizophrenia Projects (JUSP). 17720314 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease PSYGENET Genetic analysis of the TrkB gene and schizophrenia in the Japanese population: Juntendo University Schizophrenia Projects (JUSP). 17720314 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease LHGDN Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. 15647480 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease LHGDN Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains. 12921913 2003