|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting.
|
30631148 |
2019 |
|
Acute lymphocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies.
|
23285131 |
2012 |
|
Acute lymphocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Ror1 mRNA was detected in 23 of 57 (40%) ALL patients.
|
18354269 |
2007 |
|
Acute lymphocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A significantly high and uniform surface expression of ROR1 was found in CLL/hairy cell leukemia (HCL) compared to mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), myelomas, acute lymphoblastic leukemia (ALL) and myeloid leukemias (p = 0.02 to < 0.001).
|
22988987 |
2013 |
|
Acute lymphocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.
|
23153538 |
2012 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Breast adenocarcinomas expressing high levels of ROR1 were more likely to have gene expression signatures associated with EMT and had higher rates of relapse and metastasis than breast adenocarcinomas expressing low levels of ROR1.
|
23771907 |
2013 |
|
Adenocarcinoma of large intestine
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Adenocarcinoma of lung (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
The finding of ROR1-mediated proliferation signals in both tyrosine kinase inhibitor (TKI)-sensitive and -resistant tumor cells provides encouragement to develop ROR1-directed targeted therapy in lung adenocarcinoma, especially those with TKI resistance.
|
25978653 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The data show that ROR1 is homogenously expressed on a subset of ovarian cancer, triple-negative breast cancer, and lung adenocarcinomas.
|
27852699 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The receptor tyrosine kinase (RTK) ROR1 is overexpressed and of importance for the survival of various malignancies, including lung adenocarcinoma, breast cancer and chronic lymphocytic leukemia (CLL).
|
23593420 |
2013 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Ror1 mRNA was detected in 23 of 57 (40%) ALL patients.
|
18354269 |
2007 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A significantly high and uniform surface expression of ROR1 was found in CLL/hairy cell leukemia (HCL) compared to mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), myelomas, acute lymphoblastic leukemia (ALL) and myeloid leukemias (p = 0.02 to < 0.001).
|
22988987 |
2013 |
|
Adult B Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia.
|
21813176 |
2011 |
|
Adult Fibrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that IGF1R (15/15) and ROR1 (11/15) were highly expressed in sarcoma cell lines including Ewing sarcoma, osteosarcoma, alveolar or embryonal rhabdomyosarcoma, and fibrosarcoma.
|
26173023 |
2015 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Northern blots demonstrate that mRNA encoding this truncated Ror1 ('t-Rorl') is abundantly expressed in fetal and adult human CNS, in human leukemia, lymphoma cell lines, and in a variety of human cancers derived from neuroectoderm.
|
8875995 |
1996 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
ROR1 associates unfavorable prognosis and promotes lymphoma growth in DLBCL by affecting PI3K/Akt/mTOR signaling pathway.
|
30801854 |
2019 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Ror1 has recently been reported in B-cell chronic lymphocytic leukemia.
|
18354269 |
2007 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Over-expression of ROR1 gene, a member of the receptor tyrosine kinase family, has recently been reported in B-cell chronic lymphocytic leukemia.
|
18604725 |
2008 |
|
Basal-Like Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Silencing of ROR1 inhibited EMT process, cell migration, invasion, and cancer metastasis of basal-like breast cancer (BLBC) cells.
|
29774072 |
2018 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
The most significant SNPs resided in ROR1 and PLCB1, genes known to be involved in bipolar disorder and schizophrenia, respectively.
|
21494683 |
2011 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Breast adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we show that the neoplastic cells of many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma was associated with aggressive disease.
|
22403610 |
2012 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we established microphysiologic three-dimensional (3D) lung and breast cancer models that resemble architectural and phenotypical features of primary tumors and evaluated the antitumor function of receptor tyrosine kinase-like orphan receptor 1-specific (ROR1-specific) CAR T cells.
|
31415244 |
2019 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we report that crosstalk between ROR1-HER3 and the Hippo-YAP pathway promotes breast cancer bone metastasis in a long noncoding RNA-dependent fashion.
|
28114269 |
2017 |