OAS1, 2'-5'-oligoadenylate synthetase 1, 4938

N. diseases: 72; N. variants: 11
Disease: Virus Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.320 GeneticVariation group BEFREE The SS risk allele of rs10774671 has been shown by others to be associated with reduced OAS1 enzymatic activity and ability to clear viral infections, as well as reduced responsiveness to IFN treatment. 28640813 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.320 Biomarker group BEFREE Although still preliminary, a few recent observations also substantiate a possible role for OAS1 in human susceptibility to viral infections (West Nile virus, SARS, etc.) and its possible involvement in some other diseases such as type 1 diabetes and multiple sclerosis. 18727488 2008
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.320 Biomarker group CTD_human This genetic polymorphism makes OAS1 an excellent candidate for a human gene that influences host susceptibility to viral infection. 15732009 2005