|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Mental Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Depressive disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Influenza
|
0.310 |
Biomarker
|
disease |
BEFREE |
Additionally, significant DEGs in module 2, including radical S‑adenosyl methionine domain containing 2 (RSAD2), 2'‑5'‑oligoadenylate synthetase 2 (OAS2), myxovirus (influenza virus) resistance 1 (MX1) and ISG15 ubiquitin‑like modifier (ISG15), were predominantly associated with immune function pathways.
|
27356888 |
2016 |
|
Influenza
|
0.310 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Unipolar Depression
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Unipolar Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Major Depressive Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |
|
Drug-induced depressive state
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue.
|
22152193 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Four Novel Loci in Asthma in European American and African American Populations.
|
27611488 |
2017 |
|
Hepatitis C
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
On multivariate analysis, the independent predictors of gene expression were hepatitis C (Mx1, OAS2, PKR and IFI16), donor age (IFI16) and recipient gender (IRF7A) (P < .05 for all).
|
21789480 |
2011 |
|
Hepatitis C
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The HLA-A, STAT1, and OAS2 genes were highly enriched and up-regulated discovered in the HCV-infected HCC.
|
31660973 |
2019 |
|
Hepatitis C
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.
|
28139728 |
2017 |
|
Psoriasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Despite differences in the specific residues targeted for methylation/demethylation, OAS2 expression was upregulated in all conditions and correlations between methylation and expression were seen in psoriasis and tongue SCC.
|
27572959 |
2016 |
|
Psoriasis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Increased expression of four antiviral proteins (MX1, BST2, ISG15 and OAS2) has been reported in psoriatic skin and genetic studies of psoriasis have identified susceptibility genes in antiviral pathways.
|
25809693 |
2015 |
|
Squamous cell carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
To provide further insight into the epigenetic regulation of OAS2, we performed pyrosequencing to detect OAS2 DNA methylation status at 11 promoter and first exon located CpG sites in psoriasis (n = 12) and two common subtypes of squamous cell carcinoma (SCC) of the head and neck: tongue (n = 12) and tonsillar (n = 11).
|
27572959 |
2016 |
|
Chikungunya Fever
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter region of CD209 gene (rs735239, rs4804803, rs2287886) and OAS1 (rs1131454 and rs10774671), OAS2 (rs15895 and rs1732778), and OAS3 (rs2285932 and rs2072136) genes were investigated in 100 patients with CHIKV infection and 101 healthy controls to find out the association of these polymorphisms with CHIKV infection.
|
26398832 |
2016 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, GSN and OAS2 were positively and negatively associated with recurrence, respectively, suggesting their potential value as predictors of recurrence or therapeutic targets in CRC patients.
|
30148861 |
2018 |
|
Dengue Fever
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The two locus haplotype of OAS2 G-G was significantly higher in all patient groups [DEN vs. HCs, P=0.0041, P corrected (Pc)=0.012, Odds ratio (OR) 1.73 95% CI 1.16-2.59] while the four locus haplotype of OAS3-OAS2 C-G-A-G was significantly lower in all dengue patient groups [DEN vs. HCs, P=0.0054, Pc=0.0486, OR 0.09, 95% CI 0.00-0.64] compared to controls.
|
23337612 |
2013 |
|
Dermatitis, Atopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of PKR and OAS2 was also significantly decreased in skin biopsies from ADEH(+) subjects compared with patients with atopic dermatitis without a history of eczema herpeticum and nonatopic subjects.
|
21208652 |
2011 |
|
Eczema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of PKR and OAS2 was also significantly decreased in skin biopsies from ADEH(+) subjects compared with patients with atopic dermatitis without a history of eczema herpeticum and nonatopic subjects.
|
21208652 |
2011 |
|
Encephalitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In EV71-infected patients, the CA genotype distribution (P=0.007), A allele frequency (OR 1.32,95% CI 1.0-1.7, P=0.034) and CA+AA carriage frequency (P=0.003) of OAS2 rs739901 5'-flanking were obviously elevated as compared with controls, but there were no statistically significant differences between mild cases and encephalitis cases.
|
30128873 |
2018 |
|
Chronic Fatigue Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |