OAS3, 2'-5'-oligoadenylate synthetase 3, 4940

N. diseases: 72; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.030 Biomarker disease BEFREE <i>In vitro</i> expression of the TRAF6 protein, phosphorylated transcription factor p65 and phosphorylated p100 in myeloma cell lines was induced by MSCs from patients with MM. 28789366 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.030 Biomarker disease BEFREE The molecular mechanism of p100 degradation has implications in multiple myeloma, a disease with constitutive activation of the noncanonical NF-κB pathway. 23211527 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.030 GeneticVariation disease BEFREE C-terminal truncations of the NFKB2 p100 gene product have been observed in a number of cases of human cutaneous T cell lymphomas, as well as human B-cell lymphomas and myelomas. 10713675 2000