Influenza
|
0.300 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Protein and fat intake interacts with the haplotype of PTPN11_rs11066325, RPH3A_rs886477, and OAS3_rs2072134 to modulate serum HDL concentrations in middle-aged people.
|
31006500 |
2020 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.
|
30718733 |
2019 |
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.
|
28485404 |
2017 |
Chronic Lymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
|
28165464 |
2017 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
Small Lymphocytic Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
|
28165464 |
2017 |
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.
|
21270382 |
2011 |
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.
|
21270382 |
2011 |
Multiple Myeloma
|
0.030 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i> expression of the TRAF6 protein, phosphorylated transcription factor p65 and phosphorylated p100 in myeloma cell lines was induced by MSCs from patients with MM.
|
28789366 |
2017 |
Dengue Fever
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue.
|
24819159 |
2015 |
Dengue Fever
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The two locus haplotype of OAS2 G-G was significantly higher in all patient groups [DEN vs. HCs, P=0.0041, P corrected (Pc)=0.012, Odds ratio (OR) 1.73 95% CI 1.16-2.59] while the four locus haplotype of OAS3-OAS2 C-G-A-G was significantly lower in all dengue patient groups [DEN vs. HCs, P=0.0054, Pc=0.0486, OR 0.09, 95% CI 0.00-0.64] compared to controls.
|
23337612 |
2013 |
Multiple Myeloma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The molecular mechanism of p100 degradation has implications in multiple myeloma, a disease with constitutive activation of the noncanonical NF-κB pathway.
|
23211527 |
2012 |
Dengue Fever
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, OAS1 p42/p46 and OAS3 p100 are likely to contribute to host defense against DEN infection and play a role in determining the outcomes of DEN disease severity.
|
19923450 |
2009 |
Multiple Myeloma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
C-terminal truncations of the NFKB2 p100 gene product have been observed in a number of cases of human cutaneous T cell lymphomas, as well as human B-cell lymphomas and myelomas.
|
10713675 |
2000 |
Optic Neuritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; <i>p</i> = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; <i>p</i> = 0.005) for the P100-N140 amplitudes.
|
31796527 |
2020 |
Multiple Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In a multivariable regression model, age and P100 latency were significant parameters for affecting AA in patients with MS (<i>p</i> < .001 and <i>p</i> = .001).
|
31172825 |
2019 |
Multiple Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
To examine the thiol-disulphide homeostasis during an optic neuritis episode in patients with multiple sclerosis and the relationship between this homeostasis and P100 wave latency.
|
30506120 |
2019 |
Optic Neuritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
To examine the thiol-disulphide homeostasis during an optic neuritis episode in patients with multiple sclerosis and the relationship between this homeostasis and P100 wave latency.
|
30506120 |
2019 |
Enterovirus Infections
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphism in OAS3 gene has been reported to be a susceptibility factor in many infected diseases, but evidence of its effect on enterovirus 71 (EV71) infection is still lacking.
|
29414184 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Moreover, we validated p100 as a direct target of miR-320a, a tumor suppressing microRNA repressing lung cancer cell migration.
|
29159900 |
2018 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells.
|
28190248 |
2017 |
Enterovirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
The effect of OAS on several infectious viral diseases has been reported; however, a study of the effect of OAS3 on enterovirus 71 (EV71) is lacking.
|
28444539 |
2017 |
Virus Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Previous work has identified that following viral infection, type I IFN signaling induces the production of the 2'-5'-oligoadenylate synthetase (OAS) family, which include OAS1, OAS2, OAS3, and OAS-like (OASL) protein.
|
28580319 |
2017 |
Diffuse Large B-Cell Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, these findings identify specific roles for p100 and p105 signaling in defining DLBCL molecular subtypes and posit MYD88/p100 signaling as a regulator for B-cell activation.
|
28368397 |
2017 |