|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Quite unexpectedly, the expression was dramatically up-regulated in the aorta in hypertensive SHR-SP/Izm rats compared with very low levels in control WKY/Izm rats, suggesting a potential role for LOX-1 in the pathogenesis of hypertension as well as atherosclerosis.
|
9494115 |
1998 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Measurement of soluble LOX-1 in vivo may provide a novel diagnostic tool for the evaluation and prediction of atherosclerosis and vascular disease.
|
11507327 |
2001 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, all these findings support the possible contribution of LOX-1 to the pathogenesis of vascular disorders, particularly atherosclerosis.
|
12163130 |
2002 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We thus propose that CD36, CLA-1 and CD68, but not SR-A and LOX-1, may play crucial roles in the progression of macrophages to foam cells, which is a key step for the initiation of atherosclerosis.
|
12238639 |
2002 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LOX-1 is upregulated in aortas of diabetic rats and thus may contribute to the pathogenesis of human diabetic atherosclerosis.
|
15001526 |
2004 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in atherosclerosis.
|
15309203 |
2004 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lectin-like oxidized low-density lipoprotein receptor (LOX-1), a recently identified receptor that plays a role in the uptake of oxidized low-density lipoproteins into endothelial cells, has a pivotal role in the pathogenesis of atherosclerosis.
|
15727724 |
2005 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a fundamental role in the pathogenesis of atherosclerosis.
|
15976314 |
2005 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The human oxidised low-density lipoprotein receptor 1 (OLR1) gene is a functional candidate for atherosclerosis.
|
16251892 |
2006 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis.
|
17022953 |
2006 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a central role in the pathogenesis of atherosclerosis.
|
18191942 |
2008 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that elevated level of palmitic acid may contribute to development of atherosclerosis through enhanced uptake of oxLDL via upregulation of LOX-1 in macrophages.
|
19782984 |
2010 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent findings on the genetics of LOX-1 and the methodology to detect it and its ligands would further facilitate the examination of the receptor's pathophysiological contribution in atherosclerosis.
|
19801851 |
2009 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
LOX-1 might play a fundamental role in the initiation and progression of atherosclerosis and have a significant role in the pathogenesis of ICVD.
|
19929426 |
2010 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oxidized low-density lipoprotein-receptor 1 (OLR-1) might be involved in the risk of atherosclerosis and its complications.
|
20136518 |
2010 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
OLR1 is important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth, suggesting a molecular connection between cancer and atherosclerosis.
|
20385360 |
2010 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a fundamental role in the genesis and progression of atherosclerosis and its complications.
|
21847544 |
2011 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review we discuss the role of ox-LDL and LOX-1 in genesis and progression of atherosclerosis.
|
21947818 |
2011 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis.
|
22347434 |
2012 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis.
|
23134583 |
2013 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset.
|
23355954 |
2013 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibiting LOX-1 may reduce blood vessel inflammation and provide a therapeutic option to limit atherosclerosis progression.
|
24068192 |
2013 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been well confirmed ox-LDL plays key roles in the development of atherosclerosis via binding to LOX-1 and inducing apoptosis in vascular endothelial cells.
|
24252910 |
2013 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, Hcy-induced atherosclerosis was closely associated with induced hypomethylation status in the blood vessel, and this process was partially mediated by LOX-1 DNA methylation.
|
24938465 |
2014 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results indicate that LPS up-regulates LOX-1, at least in part through activation of the Erk1/2 signaling pathway, followed by augmented cellular oxLDL uptake, thus highlighting a critical role of TLR4-mediated aberrant LOX-1 signaling in the pathogenesis of atherosclerosis.
|
25348362 |
2015 |