|
Hypertensive disease
|
0.540 |
Biomarker
|
group |
BEFREE |
Soluble LOX-1 (sLOX-1), a fragment of the main LOX-1 molecule, is being investigated as a diagnostic marker because it has been shown to be present in increased quantities in patients with hypertension, diabetes, metabolic syndrome and coronary artery disease.
|
31336709 |
2019 |
|
Hypertensive disease
|
0.540 |
GeneticVariation
|
group |
BEFREE |
The role of genetic polymorphisms in the LOX1 gene, however, remains unclear in the development of left ventricular hypertrophy (LVH) for patients with hypertension.
|
24480971 |
2014 |
|
Hypertensive disease
|
0.540 |
Biomarker
|
group |
CTD_human |
Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole.
|
22352330 |
2012 |
|
Hypertensive disease
|
0.540 |
AlteredExpression
|
group |
BEFREE |
However, LOX-1 expression was elevated in the aorta but not the kidneys of spontaneously hypertensive rats, which exhibited hypertension but minor glomerulosclerotic changes.
|
11004213 |
2000 |
|
Hypertensive disease
|
0.540 |
Biomarker
|
group |
RGD |
Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1).
|
9494115 |
1998 |
|
Hypertensive disease
|
0.540 |
Biomarker
|
group |
BEFREE |
Quite unexpectedly, the expression was dramatically up-regulated in the aorta in hypertensive SHR-SP/Izm rats compared with very low levels in control WKY/Izm rats, suggesting a potential role for LOX-1 in the pathogenesis of hypertension as well as atherosclerosis.
|
9494115 |
1998 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
BEFREE |
The cardiac lectin-like oxidized low-density-lipoprotein receptor-1 is activated by oxidative stress in ischaemia-reperfusion injury, inducing apoptosis in cardiomyocytes through the deleterious NF-kB pathway, while the administration of anti-lectin-like oxidized low-density-lipoprotein receptor-1 antibody suppresses apoptosis and reduces the extent of myocardial infarction.
|
31782085 |
2020 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In humans, LOX-1 gene polymorphisms were associated with increased susceptibility to myocardial infarction.
|
23935243 |
2013 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
BEFREE |
The lectin-like oxidized LDL receptor LOX-1 (encoded by OLR1) is believed to play a key role in atherogenesis and some reports suggest an association of OLR1 polymorphisms with myocardial infarction (MI).
|
18384690 |
2008 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
BEFREE |
LOX-1 is increasingly viewed as a vascular disease biomarker and a potential therapeutic target in heart attack and stroke prevention.
|
18092947 |
2008 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Recently, a 3'-UTR (188 C>T) SNP in the OLR1 gene has been reported to be associated with coronary artery stenosis and myocardial infarction.
|
16829343 |
2006 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction (MI) susceptibility.
|
15976314 |
2005 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Recently, LOX-1 gene polymorphism (G501C) was reported to be associated with myocardial infarction (MI).
|
15562935 |
2004 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
CTD_human |
Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction.
|
14684693 |
2003 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
CTD_human |
These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI.
|
12646194 |
2003 |
|
Myocardial Infarction
|
0.490 |
Biomarker
|
disease |
LHGDN |
Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction.
|
14684693 |
2003 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI.
|
12646194 |
2003 |
|
Myocardial Infarction
|
0.490 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Heart failure
|
0.320 |
Biomarker
|
disease |
BEFREE |
In conclusion, α1-antitrypsin and lectin-like oxidized low-density-lipoprotein receptor-1 seem to represent two good markers in HF and therapeutic targets, whereas galectin-3 does not.
|
31782085 |
2020 |
|
Congestive heart failure
|
0.320 |
Biomarker
|
disease |
BEFREE |
In conclusion, α1-antitrypsin and lectin-like oxidized low-density-lipoprotein receptor-1 seem to represent two good markers in HF and therapeutic targets, whereas galectin-3 does not.
|
31782085 |
2020 |
|
Heart failure
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.
|
27195769 |
2016 |
|
Congestive heart failure
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.
|
27195769 |
2016 |
|
Heart failure
|
0.320 |
Biomarker
|
disease |
CTD_human |
Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole.
|
22352330 |
2012 |
|
Congestive heart failure
|
0.320 |
Biomarker
|
disease |
CTD_human |
Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole.
|
22352330 |
2012 |
|
Cardiomyopathies
|
0.310 |
Biomarker
|
group |
BEFREE |
Cardiomyopathy was induced by a single intraperitoneal injection of DOX into wild-type (WT) mice and LOX-1 knockout (KO) mice.
|
27195769 |
2016 |