Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
CTD_human |
Increased brain mOR binding in frontal and temporal cortical regions is a significant independent predictor of time to relapse to cocaine use, suggesting an important role for the brain endogenous opioid system in cocaine addiction.
|
18762918 |
2008 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
CTD_human |
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.
|
12815747 |
2003 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
BEFREE |
Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to treat cocaine addiction, but the paucity of molecules co-activating both receptors with comparable potency has hampered this line of research.
|
29180970 |
2017 |
Cocaine Dependence
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Studies of polymorphisms in the mu opioid receptor gene, which encodes the receptor target of some endogenous opioids, heroin, morphine, and synthetic opioids, have contributed substantially to knowledge of genetic influences on opiate and cocaine addiction.
|
15734726 |
2005 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence.
|
11092766 |
2000 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
CTD_human |
An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice.
|
16893609 |
2006 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
BEFREE |
Further modification of this pendant resulted in retention of KOR agonism and the addition of mu opioid receptor (MOR) partial agonism, a bifunctional profile with potential to be used in the treatment of cocaine addiction.
|
31199621 |
2019 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.
|
22882391 |
2013 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Studies of polymorphisms in the mu opioid receptor gene, which encodes the receptor target of some endogenous opioids, heroin, morphine, and synthetic opioids, have contributed substantially to knowledge of genetic influences on opiate and cocaine addiction.
|
15734726 |
2005 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
BEFREE |
Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence.
|
11092766 |
2000 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
BEFREE |
Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.
|
22882391 |
2013 |