|
Substance Dependence
|
0.400 |
Biomarker
|
disease |
CTD_human |
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.
|
27192616 |
2016 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
|
26392368 |
2016 |
|
Substance Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other candidate genes associated with substance dependence phenotypes in Native Americans include OPRM1, CRN1, COMT, GABRA2, MAOA, and HTR3-B.
|
23377636 |
2013 |
|
Substance Dependence
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our findings suggest that OPRM1 promoter hypermethylation may increase the risk for AD and other substance dependence disorders.
|
22914673 |
2012 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies of the association of the C17T polymorphism of the mu opiate receptor gene with substance dependence compared cases with substance dependence to controls and usually found no significant association.
|
21070507 |
2012 |
|
Substance Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additional research is needed to determine whether these findings reflect no role for OPRM1 in determining risk for SD or whether another polymorphism in the gene influences receptor function and risk for SD.
|
16387451 |
2006 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analyses confirmed the association between OPRM1 variants and substance dependence, when sex and age of subjects and alleles, genotypes, haplotypes or diplotypes of five tag SNPs were considered.
|
16476706 |
2006 |
|
Substance Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
This region harbors OPRM1, a candidate gene for substance dependence.
|
16451620 |
2005 |
|
Substance Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific.
|
12815747 |
2003 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence.
|
12960749 |
2003 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings and analyses suggest that the OPRM1 +118 polymorphism is a general risk gene for substance dependence, but is not specific to a particular substance.
|
11840318 |
2002 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In both patient samples and by both methods we were unable to corroborate the hypothesis of OPRM1 A118G polymorphism as a particular risk factor for any kind of substance dependence including opioid addiction.
|
11424981 |
2001 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The three opioid receptor genes, and in particular the mu and delta loci (OPRM1 and OPRD1, respectively), are compelling candidates to influence risk for substance dependence.
|
10982041 |
2000 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence.
|
11092766 |
2000 |
|
Substance Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of genetic variation affecting OPRM1 expression or mu opioid receptor function would be an important step towards understanding the origins of inter-individual variation in response to mu opioid receptor ligands and in diseases of substance dependence.
|
9399694 |
1998 |
|
Substance Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further studies of the association between alleles of the OPRM1 gene and substance dependence appear warranted, particularly if they use a family-based approach to control for population stratification.
|
9756053 |
1998 |