|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Short stature
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Enterovirus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Therefore, the long-term, compound-induced reduction of OSBP in cells presents a new route to broad spectrum anti- Enterovirus activity, including as a novel route to antiviral prophylactic treatment through small molecule targeting a human host protein.
|
30576108 |
2019 |
|
Enterovirus Infections
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The OSW-1-induced reduction of OSBP levels inhibited Enterovirus replication prophylactically in cells.
|
31271764 |
2019 |
|
Enterovirus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
This work supports a two-step resistance model of enterovirus to PI4KB/OSBP inhibitors involving unique recessive epistasis of 3A and 2B and offers insights into a potential evolutionary pathway of enterovirus toward independence from the PI4KB/OSBP pathway.
|
30919621 |
2019 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
OSBP exchanges PI(4)P with cholesterol, thus removing PI(4)P from the HCV RO.
|
31484747 |
2019 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
RNA interference (RNAi)-mediated knockdown identified several hitherto unknown HCV dependency factors, such as steroidogenic acute regulatory protein-related lipid transfer domain protein 3 (STARD3), oxysterol-binding protein-related protein 1A and -B (OSBPL1A and -B), and Niemann-Pick-type C1 (NPC1), all residing at late endosome and lysosome membranes and required for efficient HCV RNA replication but not for replication of the closely related dengue virus.
|
29046459 |
2018 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
The antiviral activity of TTP-8307 extends to other viruses that require OSBP, namely the picornavirus encephalomyocarditis virus and the flavivirus hepatitis C virus.
|
28088354 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The facts that some natural anti-cancer molecules block OSBP and that many viruses hijack the OSBP cycle for the formation of intracellular replication organelles highlight the importance and potency of OSBP-mediated lipid exchange.
|
29596003 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The role of oxysterol-binding protein and its related proteins in cancer.
|
28733164 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The role of oxysterol-binding protein and its related proteins in cancer.
|
28733164 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The facts that some natural anti-cancer molecules block OSBP and that many viruses hijack the OSBP cycle for the formation of intracellular replication organelles highlight the importance and potency of OSBP-mediated lipid exchange.
|
29596003 |
2018 |
|
Solid Neoplasm
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We also analysed the presence of mRNA for HLM, a human oxysterol-binding protein homologue recently described as a potential marker for blood dissemination of solid tumors.
|
11295104 |
2001 |
|
Solid Neoplasm
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors.
|
10446991 |
1999 |
|
Mycoses
|
0.010 |
Biomarker
|
group |
BEFREE |
The anti-fungal β-sitosterol targets the yeast oxysterol-binding protein Osh4.
|
31347760 |
2020 |
|
liposarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our findings, OSBP serves as a potential therapeutic target for human liposarcoma.
|
30415825 |
2018 |
|
Adult Liposarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our findings, OSBP serves as a potential therapeutic target for human liposarcoma.
|
30415825 |
2018 |
|
Childhood Liposarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on our findings, OSBP serves as a potential therapeutic target for human liposarcoma.
|
30415825 |
2018 |
|
Resistant hypertensive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cohort consisted of 4 groups: severe resistant hypertension (office systolic blood pressure [OSBP] ≥ 160 mm Hg) treated with a unidirectional catheter (group 1; n = 14); severe resistant hypertension treated with a multidirectional catheter (group 2; n = 18); moderate resistant hypertension (OSBP 140-159 mm Hg) treated with a multidirectional catheter (group 3; n = 5); and recurrent severe resistant hypertension, after an initial response to RF RDN (group 4; n = 2).
|
29921526 |
2018 |
|
Isolated systolic hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with isolated systolic hypertension had a significantly smaller reduction in OSBP after 6 months compared with patients with combined systolic/diastolic hypertension (-16.2 mm Hg ± 18.5 vs -9.9 mm Hg ± 33.4; P < .005).
|
29921526 |
2018 |
|
Hypocholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
OSBP and Sac1 co-localized at apparent ER-Golgi contact sites in response to 25-hydroxycholesterol (25OH), cholesterol depletion and p38 MAPK inhibitors.
|
28471037 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype.
|
26812496 |
2016 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.
|
27588468 |
2016 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
OSBP, a 7-amino-acid peptide with high affinity for human ovarian cancer HO8910 cells, was conjugated to the cell-penetrating peptide (TAT) to form a tumor-selective peptide (TAT-OSBP), which was further conjugated with EGFP or MKK6(E).
|
26495757 |
2015 |
|
AMYOTROPHIC LATERAL SCLEROSIS 8 (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hence, we propose that the ALS8 mutation impairs the interaction of Vap with Osbp, resulting in hypomorphic defects that might contribute to the pathology of ALS8.
|
24271015 |
2014 |