Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, OTX2 expression might be a predictive factor for leptomeningeal metastases of medulloblastoma.
|
30797919 |
2019 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study provides mechanistic insight into the networks controlled by OTX2 in MB stem/progenitor cells and reveals novel roles for axon guidance genes and their downstream effectors as putative tumor suppressors in MB.
|
29377567 |
2018 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression.
|
29490009 |
2018 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OTX2 is overexpressed in all types of medulloblastomas, except in Shh-dependent type 2 medulloblastomas, although it has GCPs as cell-of-origin.
|
30100614 |
2018 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our studies thus show that OTX2 controls the regulatory landscape of Group 3 medulloblastoma through cooperative activity at enhancer elements and contributes to the expression of critical target genes.<b>Significance:</b> The gene regulation mechanisms that drive medulloblastoma are not well understood.
|
28213356 |
2017 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Involvement of the Otx2 gene dysfunction in both group 4 subtype medulloblastoma and mirror-image dextrocardia with situs inversus points to a possible mechanism that dysfunction of a shared signaling pathway such as Otx2 might be the underlying cause of these 2 conditions in this family.
|
28844926 |
2017 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recent studies have revealed that Group 3 and Group 4 medulloblastomas show marked overexpression of OTX2 with a concurrent amplification of the MYC and MYCN oncogenes, respectively, correlating with anaplasticity and unfavorable patient outcomes.
|
28401018 |
2017 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, OTX2 is oncogenic and promotes self-renewal of trans-hENs and Groups 3 and 4 MB independent of pluripotent gene expression.
|
26398939 |
2015 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Five differentially expressed genes in medulloblastoma (GLI1, SPHK1, SHROOM2, PDLIM3, and OTX2) were found to associate with Hh pathway activation status.
|
25473003 |
2015 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OTX2, an oncogenic miR-206 target, overexpressed in all non-SHH medulloblastomas, is known to inhibit myogenic differentiation of medulloblastoma cells.
|
25859932 |
2015 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, OTX2 is a known oncogenic driver in medulloblastoma, a condition that was diagnosed in the proband during the course of the study.
|
24816892 |
2014 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This work characterizes for the first time the mechanisms of OTX2 overexpression in medulloblastoma.
|
25198066 |
2014 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Silencing of OTX2 in D425 medulloblastoma cells resulted in downregulation of polycomb genes such as EZH2, EED, SUZ12 and RBBP4 and upregulation of H3K27 demethylases KDM6A, KDM6B, JARID2 and KDM7A.
|
23179372 |
2013 |
Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have also established the OTX2 gene as an oncogene for medulloblastoma, a malignant brain tumour originating in the cerebellum.
|
23523800 |
2013 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we have sought to determine the functional consequences of Otx2 overexpression in the mouse hindbrain to characterize its potential role in medulloblastoma tumorigenesis and identify the cell types responsive to this lineage-specific oncogene.
|
22558385 |
2012 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Conversely, inducing myogenic conversion of medulloblastoma cells led to the loss of OTX2 expression.
|
22986744 |
2012 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We generated D425 medulloblastoma cells in which endogenous OTX2 can be silenced by inducible shRNA.
|
21964830 |
2012 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest an important functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma.
|
22016811 |
2011 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings define OTX2 as an important oncogenic driver in medulloblastoma.
|
20028867 |
2010 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We therefore generated MED8A and DAOY medulloblastoma cell lines with doxycycline-inducible OTX2 expression.
|
21047732 |
2010 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In 15 cases, we also examined expression of OTX2, a transcription factor recently indicated as a positive marker of medulloblastomas originating from cerebellar granule precursors.
|
17522332 |
2007 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analysis of a series of classic medulloblastomas detected OTX2 protein expression in 83 of 107 (78%) cases.
|
16462208 |
2006 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
OTX2 transcript was highly and specifically expressed in medulloblastoma or developing cells.
|
15705863 |
2005 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OTX2 transcript was highly and specifically expressed in medulloblastoma or developing cells.
|
15705863 |
2005 |