Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, OTX2 expression might be a predictive factor for leptomeningeal metastases of medulloblastoma.
|
30797919 |
2019 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo.
|
30100614 |
2018 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression.
|
29490009 |
2018 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study provides mechanistic insight into the networks controlled by OTX2 in MB stem/progenitor cells and reveals novel roles for axon guidance genes and their downstream effectors as putative tumor suppressors in MB.
|
29377567 |
2018 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our studies thus show that OTX2 controls the regulatory landscape of Group 3 medulloblastoma through cooperative activity at enhancer elements and contributes to the expression of critical target genes.<b>Significance:</b> The gene regulation mechanisms that drive medulloblastoma are not well understood.
|
28213356 |
2017 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OTX2 is the member of a highly conserved family of bicoid-like homeodomain transcription factors responsible for the regulation of cerebellar development and of current investigational interest in the tumorigenesis of medulloblastoma.
|
28401018 |
2017 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Involvement of the Otx2 gene dysfunction in both group 4 subtype medulloblastoma and mirror-image dextrocardia with situs inversus points to a possible mechanism that dysfunction of a shared signaling pathway such as Otx2 might be the underlying cause of these 2 conditions in this family.
|
28844926 |
2017 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Five differentially expressed genes in medulloblastoma (GLI1, SPHK1, SHROOM2, PDLIM3, and OTX2) were found to associate with Hh pathway activation status.
|
25473003 |
2015 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By contrast, OTX2 is oncogenic and promotes self-renewal of trans-hENs and Groups 3 and 4 MB independent of pluripotent gene expression.
|
26398939 |
2015 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OTX2, an oncogenic miR-206 target, overexpressed in all non-SHH medulloblastomas, is known to inhibit myogenic differentiation of medulloblastoma cells.
|
25859932 |
2015 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This work characterizes for the first time the mechanisms of OTX2 overexpression in medulloblastoma.
|
25198066 |
2014 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, OTX2 is a known oncogenic driver in medulloblastoma, a condition that was diagnosed in the proband during the course of the study.
|
24816892 |
2014 |
Adult Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have also established the OTX2 gene as an oncogene for medulloblastoma, a malignant brain tumour originating in the cerebellum.
|
23523800 |
2013 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Silencing of OTX2 in D425 medulloblastoma cells resulted in downregulation of polycomb genes such as EZH2, EED, SUZ12 and RBBP4 and upregulation of H3K27 demethylases KDM6A, KDM6B, JARID2 and KDM7A.
|
23179372 |
2013 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We generated D425 medulloblastoma cells in which endogenous OTX2 can be silenced by inducible shRNA.
|
21964830 |
2012 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Conversely, inducing myogenic conversion of medulloblastoma cells led to the loss of OTX2 expression.
|
22986744 |
2012 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we have sought to determine the functional consequences of Otx2 overexpression in the mouse hindbrain to characterize its potential role in medulloblastoma tumorigenesis and identify the cell types responsive to this lineage-specific oncogene.
|
22558385 |
2012 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest an important functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma.
|
22016811 |
2011 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings define OTX2 as an important oncogenic driver in medulloblastoma.
|
20028867 |
2010 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We therefore generated MED8A and DAOY medulloblastoma cell lines with doxycycline-inducible OTX2 expression.
|
21047732 |
2010 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The OTX2 gene was amplified in the medulloblastoma cell line D425 and mRNA and protein data showed expression in 114 of 152 medulloblastomas (75%), but not in postnatal cerebellum.
|
16462208 |
2006 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
OTX2 transcript was highly and specifically expressed in medulloblastoma or developing cells.
|
15705863 |
2005 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of OTX2 expression by siRNAs inhibited medulloblastoma cell growth in vitro, whereas pharmacologic doses of all-trans retinoic acid repressed OTX2 expression and induced apoptosis only in medulloblastoma cell lines that expressed OTX2.
|
15705891 |
2005 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among those transcripts with a higher expression in medulloblastoma were the genes for ZIC1 protein and the OTX2 gene, both of which are expressed in the cerebellar germinal layers.
|
11015565 |
1999 |