Nuclear receptor liver receptor homolog-1 (LRH-1, <i>NR5A2</i>) is proved to play a positive role in several cancers including breast cancer, pancreatic cancer and intestinal cancer in recent years.
The results of this study support the hypothesis that suppression of LRH-1 may potentially be beneficial in the tissue specific regulation of aromatase expression in post menopausal breast cancer.
LRH-1 mRNA expression was low in normal breast tissue but markedly elevated in both breast carcinoma tissue and adipose tissue surrounding the tumor invasion (thereby paralleling aromatase expression).
Analysis of breast cancer samples reveals that a high LRH-1 level is inversely correlated with CDKN1A expression in breast cancer patients and is associated with poor prognosis.