|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that the hypoxic and unstable oxygenation microenvironment of a tumor might be crucial for prx1 up-regulation.
|
17234762 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression levels of Prx1, nuclear NFκB, vimentin and Snail were higher in the tumors from smokers with OSCC than in those from non-smokers with OSCC or the healthy controls.
|
27259998 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prx1 knockdown also augmented the inhibitory effects of docetaxel on tumor growth.
|
23615915 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nicotine, a tumor promoter in tobacco, can increase Peroxiredoxin (Prx1) and nicotinic acetylcholine receptors (nAChRs) in oral squamous cell carcinoma (OSCC).
|
29088845 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously deleted and epigenetically silenced in isocitrate dehydrogenase 1 or 2 (IDH)-mutant and 1p/19q-codeleted oligodendroglial tumors.
|
29582423 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Transcript expression of PRDX1-6 in PCa was evaluated in cancer gene microarray datasets, whereas protein expression was evaluated by immunoblotting in prostate cell lines, and by immunohistochemistry (IHC) in prostate tissue microarrays (TMAs) containing tumor (n = 80) and control (n = 17) tissues.
|
21031435 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Prx I and Trx1 are overexpressed in human breast carcinoma and the expression levels are associated with tumor grade.
|
19566940 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice lacking the peroxiredoxin Prdx1 exhibit an increased incidence of tumor formation, whereas baker's yeast (<i>Saccharomyces cerevisiae</i>) lacking the orthologous peroxiredoxin Tsa1 exhibit a mutator phenotype.
|
30486489 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We demonstrated that positive ILK and PRDX1 expressions were significantly associated with large tumor size, high TNM stage, lymph node metastasis, and invasion of SC/ASC and AC.
|
23065574 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Modified Txn system function and post-translational regulation may therefore play a significant role in pancreatic tumorigenesis by altering Kras effector phosphorylation and inhibiting the tumor suppressive redox functions of Prdx1.
|
29190947 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The membrane array and immunochemical staining data showed that PrxI, but not p53, was significantly associated with the tumor burden.
|
20732753 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The tumors that highly expressed Prdx1 (42/60) exhibited higher tumor grade and lymph node metastasis than those with low expression of Prdx1 (18/60) (p < 0.05).
|
29673884 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Either knockdown of CSE by shRNA (shCSE) or its inhibition by PAG decreased SW480 cell proliferation, migration, and tumor xenograft growth in nude mice.
|
25193114 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PRDX-1 knockdown transiently slowed tumour growth rates and sensitised them to IR in vivo.
|
21863242 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Disulfide bonds in PAG enables a rapid disassembly of PAG micelles in response to reducing agents and to release all loaded drugs (DTX, GA and MMP-9 shRNA) at tumor sites.
|
29288085 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Blocking PRDX1 by its inhibitor, Conoidin A (CoA), suppresses AR signaling, PCa cell proliferation, and xenograft tumor growth even under androgen-deprived conditions.
|
31477836 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
|
17084559 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that on H<sub>2</sub>O<sub>2</sub> exposure, transcription of tumor suppressive miRNAs let-7b and let-7c is regulated by FOXO3 or PRDX1 expression levels and that let-7c is a novel target for FOXO3.
|
28398822 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PA and GPA induce cell apoptosis through reducing the reactive oxygen species level caused by upregulated PRDX1 mRNA and protein level subsequently and exhibit potent antitumor efficacy in nude mice bearing ACHN xenografts, with increasing PRDX1 expression in tumor.
|
31298537 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PRDX1-regulated signaling pathways play an important role in the progression and metastasis of human tumours, especially in breast, esophageal and lung cancers.
|
31559796 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Likewise, xenotransplanted PRDX1-deficient MCF-7 cells presented a retarded tumour growth.
|
30287919 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a critical player in redox regulation of cancer cells, inhibition of peroxiredoxin-1 (Prx-1) may be an effective option for enhancing the tumor response to radiation.
|
25607351 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma.
|
24009050 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High levels of LINC00460 and PRDX1 expression were positively associated with lymph metastasis, pathological differentiation and tumor size in HNSCC patients.
|
31429766 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Following DMBA treatment, mice fed ZD had higher oxidative stress in mammary tissue that correlated with reduced levels of peroxiredoxin-1 and p53 and tended to have shorter tumor latency and greater incidence of non-palpable tumors.
|
26707944 |
2016 |