|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
BEFREE |
PRDX1-regulated signaling pathways play an important role in the progression and metastasis of human tumours, especially in breast, esophageal and lung cancers.
|
31559796 |
2019 |
|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
BEFREE |
Recent studies have found that PRDX1 and/or PRDX1-regulated ROS-dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers.
|
27653015 |
2017 |
|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that Prx1 may modulate the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis.
|
23615915 |
2013 |
|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
CTD_human |
Peroxiredoxin 1 (PRX1) was detected as a novel plasma marker for lung cancer (p=0.001).
|
22537621 |
2012 |
|
Malignant neoplasm of lung
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target.
|
18413821 |
2008 |
|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
BEFREE |
There was also an increased amount of oxidized form of Prx I and a putative truncated form of Prx III in lung cancer samples when analysed on two-dimensional electrophoresis.
|
16635084 |
2006 |
|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
BEFREE |
In this study, we further investigated the role of Prx I and p53 on lung cancer growth and the response to treatment in vitro and in vivo.
|
17084559 |
2006 |
|
Malignant neoplasm of lung
|
0.370 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the role of peroxiredoxin I (Prx I) in lung cancer cell growth in vitro and in vivo and its influence on these tumor cells' sensitivity to radiotherapy.
|
16414373 |
2006 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
PRDX1 was expressed at lower levels in HCC tissues than in adjacent non-cancerous tissues, and PRDX1 was found to be an independent risk factor for disease-free survival and overall survival.
|
29377617 |
2018 |
|
Esophageal Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We found that an antioxidant protein peroxiredoxin I (Prx I) was upregulated in human EC tissues as well as in EC cell lines.
|
27650197 |
2017 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
|
27517622 |
2016 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Taken together, our results propose that adenanthin targets Prx I/II to kill HCC cells and its therapeutic significance warrants to be further explored in HCC patients.
|
25188510 |
2014 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1.
|
23277276 |
2013 |
|
Esophageal Neoplasms
|
0.350 |
GeneticVariation
|
group |
BEFREE |
Our data suggested that polymorphisms of Prdx 1, 2 and 6 were not associated with esophageal cancer.
|
22215146 |
2012 |
|
Esophageal Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation.
|
21468086 |
2011 |
|
Esophageal Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
Except p21, Prdx1 (reported by us) and IGFBP3, the behaviour/expression of 12 highly responsive genes has still not been reported in esophageal cancer cells.
|
17671705 |
2007 |
|
Esophageal Neoplasms
|
0.350 |
Biomarker
|
group |
CTD_human |
Comparative proteomic analysis of esophageal squamous cell carcinoma.
|
15986332 |
2005 |
|
Esophageal Neoplasms
|
0.350 |
AlteredExpression
|
group |
LHGDN |
Our results indicate that the antitumor effect of FK228 in esophageal cancer cells is shown at least in part through Prdx1 activation by modulating acetylation of histones in the promoter, resulting in tumor growth inhibition with apoptosis induction.
|
16278420 |
2005 |
|
Liver carcinoma
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that genetic alterations of the PRDX1 locus are rare events in human HCC, indicating that other genes on chromosome 1p contribute to liver carcinogenesis.
|
16254121 |
2005 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
For the cell proliferation-related genes identified, expression levels of PRDX1 were relatively high in HCC samples from men, and expression levels of PRDX3 were relatively high in HCC samples from women.
|
15703822 |
2005 |
|
Malignant neoplasm of esophagus
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
We found that an antioxidant protein peroxiredoxin I (Prx I) was upregulated in human EC tissues as well as in EC cell lines.
|
27650197 |
2017 |
|
Malignant neoplasm of esophagus
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Our data suggested that polymorphisms of Prdx 1, 2 and 6 were not associated with esophageal cancer.
|
22215146 |
2012 |
|
Malignant neoplasm of esophagus
|
0.340 |
Biomarker
|
disease |
BEFREE |
Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation.
|
21468086 |
2011 |
|
Malignant neoplasm of esophagus
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Except p21, Prdx1 (reported by us) and IGFBP3, the behaviour/expression of 12 highly responsive genes has still not been reported in esophageal cancer cells.
|
17671705 |
2007 |
|
Malignant neoplasm of esophagus
|
0.340 |
Biomarker
|
disease |
CTD_human |
Comparative proteomic analysis of esophageal squamous cell carcinoma.
|
15986332 |
2005 |