SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014848
Disease: Esophageal Achalasia
Esophageal Achalasia
0.010 Biomarker disease BEFREE Any child with non-CAH PAI should be evaluated for the presence of alacrima and/or achalasia or family history of alacrima and/or achalasia. 31435881 2020
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.010 Biomarker disease BEFREE Psoriasis diagnosis could explain 59.0% of CAM and PAI-1 variance, with a particularly strong impact on E-selectin (45.6%), VCAM-1 (32.7%), and PAI-1 (24.8%). 31758356 2020
CUI: C0037054
Disease: Sickle Cell Trait
Sickle Cell Trait
0.010 Biomarker disease BEFREE Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. 30145922 2020
CUI: C0344505
Disease: Alacrima
Alacrima
0.010 Biomarker disease BEFREE Any child with non-CAH PAI should be evaluated for the presence of alacrima and/or achalasia or family history of alacrima and/or achalasia. 31435881 2020
CUI: C1321756
Disease: Achalasia
Achalasia
0.010 Biomarker disease BEFREE Any child with non-CAH PAI should be evaluated for the presence of alacrima and/or achalasia or family history of alacrima and/or achalasia. 31435881 2020
SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME
0.010 Biomarker disease BEFREE This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients. 30145922 2020
CUI: C0004610
Disease: Bacteremia
Bacteremia
0.010 GeneticVariation disease BEFREE Coagulation disorders on admission, bacteraemia and PAI-1 genotype 5G/5G were independently associated with development of septic shock. 31300468 2019
CUI: C0013390
Disease: Dysmenorrhea
Dysmenorrhea
0.010 Biomarker phenotype BEFREE We found higher expression of PAI-1 in DIE, and an association between PAI-1 and worse dysmenorrhea. 31315131 2019
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe
0.010 GeneticVariation disease BEFREE One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood. 30669988 2019
CUI: C0018213
Disease: Graves Disease
Graves Disease
0.010 AlteredExpression disease BEFREE Induction of plasminogen activator inhibitor-1 (PAI-1, SERPINE1), a clade E member of the serine protease inhibitor (SERPIN) gene family and a prominent regulator of the pericellular proteolytic microenvironment, was one of the most highly up-regulated proteins in INF-γ- or TGF-β1-stimulated GO fibroblasts as well as in severe active GD compared to patients without thyroid disease. 30414981 2019
CUI: C0018681
Disease: Headache
Headache
0.010 Biomarker phenotype BEFREE No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls. 30697261 2019
CUI: C0020312
Disease: Hydrothorax
Hydrothorax
0.010 AlteredExpression disease BEFREE The effusion thrombin and plasminogen activator inhibitor-1 (PAI-1) levels were measured among transudative pleural effusion (TPE, <i>n</i> = 22) and TBPE (<i>n</i> = 24) patients. 31614900 2019
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior
0.010 Biomarker phenotype BEFREE The purpose of this study was to extend research on the Personality Assessment Inventory-Adolescent (PAI-A; Morey, 2007) to include an examination of mean PAI-A results and associations between the PAI-A and indicators of impulsivity in a large sample of at-risk adolescents (<i>M<sub>age</sub></i> = 16.75; 79% male; 64% Caucasian) in a military-style residential program. 31815558 2019
CUI: C0022682
Disease: Kienbock Disease
Kienbock Disease
0.010 GeneticVariation disease BEFREE The findings suggest that the PAI-1 4G/4G polymorphism is not a genetic risk for Kienböck disease. 31806394 2019
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.010 Biomarker disease BEFREE We prospectively evaluated the specificity and sensitivity of plasminogen-activator inhibitor-1 (PAI-1) and protein C as diagnostic markers of VOD in WT patients. 30865371 2019
CUI: C0030193
Disease: Pain
Pain
0.010 Biomarker phenotype BEFREE The aim of our study was to measure pain with visual analogue scale (VAS) and knee range of motion (ROM) between in patients undergoing adductor canal block (ACB) for TKA using levobupivacaine compared to periarticular levobupivacaine infiltration (PAI-L). 31116270 2019
CUI: C0036337
Disease: Schizoaffective Disorder
Schizoaffective Disorder
0.010 AlteredExpression disease BEFREE Plasma levels of PAI-1 in patients with schizoaffective disorder were significantly lower as compared to those in control subjects (P = 0.03). tPA was lower in cases as compared to controls although it did not reach statistical significance. 31125952 2019
CUI: C0036572
Disease: Seizures
Seizures
0.010 AlteredExpression phenotype BEFREE In contrast to tPA and uPAR genes, the expression of which returned to the basal level 6 hr following seizures, urokinase and plasminogen activator inhibitor-1 gene expression showed a delayed activation only at 3 days after seizures. 31587391 2019
CUI: C0040128
Disease: Thyroid Diseases
Thyroid Diseases
0.010 Biomarker group BEFREE Induction of plasminogen activator inhibitor-1 (PAI-1, SERPINE1), a clade E member of the serine protease inhibitor (SERPIN) gene family and a prominent regulator of the pericellular proteolytic microenvironment, was one of the most highly up-regulated proteins in INF-γ- or TGF-β1-stimulated GO fibroblasts as well as in severe active GD compared to patients without thyroid disease. 30414981 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.010 Biomarker disease BEFREE Conclusively, thrombin upregulates PAI-1 and MMT and may contribute to tuberculous pleural fibrosis. 31614900 2019
CUI: C0085578
Disease: Thalassemia Minor
Thalassemia Minor
0.010 Biomarker disease BEFREE In multivariate linear regression analyses, the lower values of WBC (<0.001), CRP (<0.001), homocysteine (<0.001), fibrinogen (<0.001), and PAI-1 (0.008), but not of SAA, were independently associated with thalassemia minor. 30865135 2019
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.010 AlteredExpression disease BEFREE Immunohistochemical analysis of lung adenocarcinoma tissues showed that PAI-1 expression was correlated with that of α-SMA (r = 0.71, p < 0.001). 30734495 2019
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma
0.010 Biomarker disease BEFREE Subject of this work was to study PZ and PAI-1 in patients with Hodgkin Lymphoma (HL), a malignancy with inflammatory background and relatively low incidence of thrombosis. 28952223 2019
CUI: C0220644
Disease: Childhood Hodgkin Lymphoma
Childhood Hodgkin Lymphoma
0.010 Biomarker disease BEFREE Subject of this work was to study PZ and PAI-1 in patients with Hodgkin Lymphoma (HL), a malignancy with inflammatory background and relatively low incidence of thrombosis. 28952223 2019
CUI: C0221271
Disease: Elastosis perforans serpiginosa
Elastosis perforans serpiginosa
0.010 Biomarker disease BEFREE The combination of FWT and PAI-1 AR identified the largest proportion of EPS patients at 1 year prior to diagnosis (sensitivity 100%, specificity 94%). 30478138 2019