|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Its effects on ROS production, AP-1 activity, plasminogen activator inhibitor 1 (PAI-1) gene expression, and cellular proliferation and migration were measured in response to high glucose and angiotensin II (Ang II) concentrations, two major factors in the pathogenesis of atherosclerosis in patients with diabetes and hypertension.
|
15827742 |
2005 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since NF-kappaB-mediated gene products, such as fibrinogen and PAI-1, are known to facilitate hypercoagulation, thrombosis and vascular events, we suggest that nilvadipine has a direct beneficial effect separate from its anti-hypertensive properties by inhibiting NF-kappaB-dependent gene expression and eventually inhibiting atherosclerosis.
|
15530472 |
2004 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study.
|
12719278 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this paper, we have studied the contribution of the plasminogen activation system in the development of atherosclerosis by cross-breeding apoE3-Leiden mice, which have a human-like lipid profile, with mice deficient in PAI-1 (plasminogen-activator inhibitor-1), u-PA (urokinase plasminogen activator), and t-PA (tissue plasminogen activator).
|
14515193 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Atheroprotective Mechanisms Activated by Fluid Shear Stress in Endothelial Cells.
|
12677255 |
2002 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These criteria identify targets for therapy designed to normalize expression of PAI-1 and retard progression of atherosclerosis in subjects with elevated concentrations of FFA in blood including those with insulin resistance.
|
12669679 |
2002 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased production of plasminogen activator inhibitor-1 (PAI-1) in plaques plays a role in the pathogenesis of atherosclerosis.
|
12063175 |
2002 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This overview summarizes the current knowledge on plasminogen activator inhibitor-1 (PAI-1) in the progression of atherosclerosis and the influence of MMPs in aneurysm formation.
|
11795260 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Endothelial dysfunction in patients suffering from atherosclerosis or diabetes type 2 is associated not only with suppression in release of the above mediators but also with deleterious discharge of prostaglandin endoperoxides (PGH2, PGG2), superoxide anion (O2-, peroxynitrite (ONOO-), and plasminogen activator inhibitor (PAI-1).
|
11208485 |
2001 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggests that hyperhomocysteinemia-induced atherosclerosis and/or thrombosis may be caused by homocysteine-induced stimulation of PAI-1 gene expression and secretion in the vasculatures by a mechanism independent from paracrine-autocrine activity of TGFbeta and TNFalpha.
|
10872824 |
2000 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fibrinogen, factor VII and PAI-1 genotypes and the risk of coronary and peripheral atherosclerosis: Edinburgh Artery Study.
|
10235438 |
1999 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, in addition to the markers of insulin resistance and smoking habit, gene variants of PAI-1 and ACE account for a significant portion of the between-individual variability of circulating PAI-1 antigen concentrations in a general population without clinical evidence of atherosclerosis.
|
9555861 |
1998 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Insulin-resistant states are characterized by accelerated atherosclerosis and are associated with increased plasma concentrations of insulin and plasminogen activator inhibitor type 1 (PAI-1).
|
9386151 |
1997 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with normal pairs, the tissue content of PAI-1 (ng) was increased in fatty streak lesions (n = 3, normal 35 +/- 12, fatty streak 50 +/- 8, P < or = .05); stable to decreased in moderate atherosclerosis (n = 3, normal 34 +/- 3, moderate 22 +/- 7, P = .16); and increased in severe atherosclerosis (n = 6, normal 48 +/- 9, severe 85 +/- 19, P < or = .05).
|
9409325 |
1997 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Studies in mice with targeted gene inactivation of t-PA, u-PA, PAI-1, the urokinase receptor (u-PAR), and plasminogen (Plg) revealed (1) that deficiency of t-PA or u-PA increase the susceptibility to thrombosis associated with inflammation and that combined deficiency of t-PA:u-PA or deficiency of Plg induces severe spontaneous thrombosis; (2) that vascular injury-induced neointima formation is reduced in mice lacking u-PA-mediated plasmin proteolysis, unaltered in t-PA- or u-PAR-deficient mice and accelerated in PAI-1-deficient mice, but that it can be reverted by adenoviral PAI-1 gene transfer; and (3) that atherosclerosis in mice doubly deficient in apolipoprotein E (apoE) and PAI-1 is reduced after 10 weeks of cholesterol-rich diet.
|
9186598 |
1997 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of plasminogen activator inhibitor-1 (PAI-1) mRNA in atherosclerotic human arteries suggests a linkage between PAI-1 gene expression and cellular proliferation, the fundamental feature of atherosclerosis.
|
9108786 |
1997 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
One of the well-known physiological substances that induce the PAI-1 gene is tumor necrosis factor-alpha, which also induces other possible risk factors of atherosclerosis, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1.
|
9187938 |
1997 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common variation of the DNA sequence in the promoter region, such as that occurring in the human apolipoprotein A-I and plasminogen activator inhibitor(-1) genes, may account for subtle differences in serum lipid levels and risk of atherosclerotic vascular disease in the general population.
|
8743897 |
1996 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We and others have hypothesized that the increased PAI-1 may contribute to acceleration of atherosclerosis in this condition and in other states characterized by insulin resistance as well.
|
8281664 |
1994 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of a paternal history of premature myocardial infarction on fibrinogen, factor VIIC and PAI-1 in European offspring--the EARS study. European Atherosclerosis Research Study Group.
|
8052959 |
1994 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of PAI-1 have been associated with vascular disease such as thrombosis and atherosclerosis.
|
7900096 |
1994 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In most instances, the level of PAI-1 mRNA was correlated with the degree of atherosclerosis.
|
1495992 |
1992 |