SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE Contrariwise, plasminogen activator inhibitor-1 was already significantly increased at sepsis onset, which was paralleled by significantly increased LIs in patients suffering from septic shock in comparison with both control groups. 30701381 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE Of these genes, the adverse allele (or combinations) was same in nine (ADRB2, FV, HMOX1, IL6, MBL, MIF, NOD2, PCSK9, SERPINE1), and the effect appears to be in the same direction in both sepsis and cardiovascular disease. 30660782 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE PAI-1 is a significant predictor of disease severity and all-cause mortality in sepsis. 29967603 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 AlteredExpression disease BEFREE The present study concludes that PAI-1 gene expression gets significantly increased via NF-κF signaling pathway during sepsis. 28121360 2017
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE Thrombin-induced release of plasminogen-activator-inhibitor-1 from platelets (anti-fibrinolytic event in sepsis) is inhibited by ascorbate pH-dependently. 28661424 2017
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE Study Design We describe the clinical management and treatment of PVT in a preterm newborn with a homozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) and plasminogen activator inhibitor-1 (PAI-1) genes and sepsis by Candida parapsilosis. 27603544 2016
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE In conclusion, the meta-analysis suggests that there are significant associations between SERPINE1 rs1799768 polymorphism and risk of sepsis and sepsis mortality. 26537299 2015
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE Nor did any subgroup analysis indicate a significant association.In conclusion, -675 4G/5G polymorphism in the SERPINE1 gene may not be associated with the risk of sepsis. 26559247 2015
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE The study indicates that the 4G/5G promoter polymorphism of PAI-1 gene may be related to the susceptibility to burn sepsis and that the 4G/4G genotype may be an important genetic risk factor of burn sepsis. 26345945 2015
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE This meta-analysis suggested that the PAI-1 -675 4G/5G polymorphism was a risk factor for sepsis and sepsis mortality. 23382992 2013
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE PAI-1, a key regulator for fibrinolysis and coagulation, acts as an APP during acute phase response (APR) such as acute lung injury (ALI), inflammation, and sepsis. 21945446 2011
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE We aimed to evaluate the effect of functionally relevant 4G/5G polymorphism of PAI-1 gene in pneumonia induced sepsis. 20429897 2010
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied. 16444434 2006
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease LHGDN Pleiotropic functions of plasminogen activator inhibitor-1. 15634264 2005
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease LHGDN Plasminogen activator inhibitor type 1 gene polymorphism and sepsis. 16237647 2005
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 GeneticVariation disease BEFREE The 4G/5G insertion/deletion promoter polymorphism, which leads to differences in PAI-1 production, has been demonstrated to affect the risk of developing severe complications and dying from sepsis during meningococcal infection and multiple trauma. 16237647 2005
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic disease RGD Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. 12000738 2002
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker disease BEFREE Concentrations of PAI-1 on admission correlated with presentation (sepsis or meningitis) and outcome. 10470700 1999
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 AlteredExpression disease BEFREE Impaired fibrinolysis, resulting from increased plasminogen activator inhibitor-1 (PAI-1) or reduced tissue-type plasminogen activator (t-PA) plasma levels, may predispose the individual to subacute thrombosis in sepsis and inflammation. 9269770 1997