Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Contrariwise, plasminogen activator inhibitor-1 was already significantly increased at sepsis onset, which was paralleled by significantly increased LIs in patients suffering from septic shock in comparison with both control groups.
|
30701381 |
2019 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Of these genes, the adverse allele (or combinations) was same in nine (ADRB2, FV, HMOX1, IL6, MBL, MIF, NOD2, PCSK9, SERPINE1), and the effect appears to be in the same direction in both sepsis and cardiovascular disease.
|
30660782 |
2019 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
PAI-1 is a significant predictor of disease severity and all-cause mortality in sepsis.
|
29967603 |
2018 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The present study concludes that PAI-1 gene expression gets significantly increased via NF-κF signaling pathway during sepsis.
|
28121360 |
2017 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thrombin-induced release of plasminogen-activator-inhibitor-1 from platelets (anti-fibrinolytic event in sepsis) is inhibited by ascorbate pH-dependently.
|
28661424 |
2017 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Study Design We describe the clinical management and treatment of PVT in a preterm newborn with a homozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) and plasminogen activator inhibitor-1 (PAI-1) genes and sepsis by Candida parapsilosis.
|
27603544 |
2016 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the meta-analysis suggests that there are significant associations between SERPINE1 rs1799768 polymorphism and risk of sepsis and sepsis mortality.
|
26537299 |
2015 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Nor did any subgroup analysis indicate a significant association.In conclusion, -675 4G/5G polymorphism in the SERPINE1 gene may not be associated with the risk of sepsis.
|
26559247 |
2015 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The study indicates that the 4G/5G promoter polymorphism of PAI-1 gene may be related to the susceptibility to burn sepsis and that the 4G/4G genotype may be an important genetic risk factor of burn sepsis.
|
26345945 |
2015 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that the PAI-1 -675 4G/5G polymorphism was a risk factor for sepsis and sepsis mortality.
|
23382992 |
2013 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
PAI-1, a key regulator for fibrinolysis and coagulation, acts as an APP during acute phase response (APR) such as acute lung injury (ALI), inflammation, and sepsis.
|
21945446 |
2011 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We aimed to evaluate the effect of functionally relevant 4G/5G polymorphism of PAI-1 gene in pneumonia induced sepsis.
|
20429897 |
2010 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied.
|
16444434 |
2006 |
Sepsis
|
0.300 |
Biomarker
|
disease |
LHGDN |
Pleiotropic functions of plasminogen activator inhibitor-1.
|
15634264 |
2005 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Plasminogen activator inhibitor type 1 gene polymorphism and sepsis.
|
16237647 |
2005 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The 4G/5G insertion/deletion promoter polymorphism, which leads to differences in PAI-1 production, has been demonstrated to affect the risk of developing severe complications and dying from sepsis during meningococcal infection and multiple trauma.
|
16237647 |
2005 |
Sepsis
|
0.300 |
Therapeutic
|
disease |
RGD |
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis.
|
12000738 |
2002 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Concentrations of PAI-1 on admission correlated with presentation (sepsis or meningitis) and outcome.
|
10470700 |
1999 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Impaired fibrinolysis, resulting from increased plasminogen activator inhibitor-1 (PAI-1) or reduced tissue-type plasminogen activator (t-PA) plasma levels, may predispose the individual to subacute thrombosis in sepsis and inflammation.
|
9269770 |
1997 |