|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In case of <i>PAI-1</i> polymorphism, we observed no relation between 4G4G genotype of 4G allele and ischemic stroke in children.
|
31530188 |
2020 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that PNS-Rb1 significantly reduced cerebral infarction rate, proBDNF/P75NTR/sortilin, and plasminogen activator inhibitor-1 (PAI-1) protein levels, and improved sensorimotor dysfunctions induced by ischemic stroke, upregulation of BDNF/TrkB levels, and its processing enzymes (tissue plasminogen activator, tPA) in a time-dependent manner.
|
31129909 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine whether different alleles and genotypes of I/D ACE gene and 4G/5G PAI-1 gene polymorphisms may influence outcome of rt-PA therapy in patients with IS and the occurrence of haemorrhagic transformation (HT).
|
31013014 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PAI-1 genotype dominant allele model was a risk factor for IS in patients with T2DM of Jinan, China.
|
30160528 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The variant 4G allele for the PAI-I 4G/5G polymorphism showed both genotypic ( P = .0013, χ<sup>2</sup> = 10.303; odds ratio [OR] = 3.75) as well as allelic association ( P = .0004, χ<sup>2</sup> = 12.273; OR = 1.99) with IS.
|
28460568 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Correlation with Platelet Parameters and Genetic Markers of Thrombophilia Panel (Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, β-Fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) in Ischemic Strokes.
|
26951304 |
2016 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (rs5985" genes_norm="2162">V34L, rs5985), MTHFR (677C > T - rs1801133;rs771406104;rs1455404812;s771406104" genes_norm="1636;2244;4524">A222V, rs1801133), MTHFR (1298A > C - rs1801131" genes_norm="4524">E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD).
|
27629735 |
2016 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai children with arterial ischemic stroke.
|
25284719 |
2015 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G polymorphism and ischemic stroke risk: a meta-analysis in Chinese population.
|
24472072 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that -7351C/T polymorphism of tPA and 4G/5G polymorphism of PAI-1 are not associated with stroke, while as DD genotype and D allele of tPA gene are important risk factors for ischemic stroke.
|
22240314 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and PAI-1 plasma levels in young patients with ischemic stroke.
|
21373825 |
2011 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The obtained results suggest that the 4 G/5 G polymorphism of the PAI-I gene is not a risk factor of ischemic stroke in Polish children.
|
21647848 |
2011 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke.
|
20623540 |
2010 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study population under 55 years of age there was no significant difference in the prevalence of various genetic polymorphisms, factor V, prothrombin, 5,10-methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and human platelet alloantigens) in patients with cryptogenic ischemic stroke and in patients with ischemic stroke of determined cause.
|
19934566 |
2010 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate that common polymorphisms within the PAI-1 promoter affect transcriptional activity of the PAI-1 gene in human astrocytes, thus providing a possible molecular genetic mechanism behind the association between PAI-1 promoter variants and ischaemic stroke.
|
20806116 |
2010 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that A-G-4G PAI-1 gene haplotype is associated with increased risk of small vessel disease stroke, but this study does not support an association of -844 G/A, -675 4G/5G, and HindIII G/C PAI-1 gene polymorphisms with particular etiology of ischemic stroke.
|
19154538 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ACE D/I, MTHFR C677T, beta-Fg -455A/G, beta-Fg -148T/C, PAI-1 4G/5G, and ApoE epsilon2-4 were associated with risk of ischemic stroke in Han Chinese.
|
18511872 |
2008 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of ischemic stroke: a meta-analysis.
|
17581326 |
2007 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Adding our PAI-1 results to previous studies in a meta-analysis indicated a strong association between this polymorphism and ischemic stroke (P = .0002), with no publication bias but with extreme heterogeneity.
|
17689414 |
2007 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To compare the distributions of mutations/polymorphisms in genes affecting hemostasis (factor V Leiden - FVL, FV H1298R-FVR2, FII 20210A, b-Fib 455G>A, FXIII V34L, PAI-1 4G, HPA-1b) or homocysteine metabolism (MTHFR C677T, MTHFR A1298C) among 90 children with arterial ischemic stroke (AIS) and 103 controls, and to associate the carriage of these mutations/polymorphisms with their corresponding proteins in children with AIS.
|
16567932 |
2006 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of tPA and PAI-1 antigen at follow-up were independently associated with overall ischemic stroke. tPA-antigen differed by stroke subtype and was highest among those with large-vessel disease and cardioembolic stroke.
|
16179568 |
2005 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied the relationship between ischemic stroke and the PAI-1 4G/5G polymorphism and PAI-1 antigen levels.
|
15630497 |
2005 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke.
|
12960956 |
2003 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Determinants of plasminogen activator inhibitor-1 in South Asians with ischaemic stroke.
|
12187010 |
2002 |