|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAI-1 activity and antigen levels were measured from all blood samples and the PAI-1 4G/5G polymorphism was determined.
|
31637872 |
2019 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of venous thrombotic risk influenced by PAI-1 genotype, showed no influence of PAI-1 4G/5G gene variant in comparison with 5G/5G genotype (OR 0.57 95% CI; 0.27-1.20).Decreased fibrinolytic activity increased, whereas PAI-1 4G/5G polymorphism did not influence venous thrombosis risk in this study.
|
28777103 |
2018 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Various studies have investigated the risk of recurrent spontaneous abortion (RSA) with plasminogen activator inhibitor-1 ( PAI-1) 4G/5G polymorphism.
|
28395596 |
2017 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The variant allele 4G of PAI-1 4G/5G polymorphism and higher plasma PAI-1 levels were found to be significantly associated with IS in young Asian Indians.
|
28460568 |
2017 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
(1) Plasma PAI-1 level was elevated in Type 2 diabetic patients; (2) The level of plasma PAI-1 is closely related to PAI-1 gene 4G/5G polymorphism and (3) PAI-1 4G/5G polymorphism is associated with the development and progression of predominant proteinuria diabetes nephropathy.
|
26616527 |
2016 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to assess serum PAI-1 and PAI-1 4G/5G polymorphism in hepatitis C virus (HCV)-induced HCC, HCV-induced liver cirrhosis, and viral infection-free apparently healthy control subjects.
|
27459171 |
2016 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this article, we discuss the pathophysiology of hypofibrinolysis associated with elevated PAI-1 levels and the PAI-1 4G/5G polymorphism.
|
27287941 |
2016 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined the PAI-1 4G/5G polymorphism and plasma PAI-1 concentrations in all patients.
|
26066833 |
2015 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current study tried to investigate in parallel the association of PAI-1 activity with the PAI-1 4G/5G polymorphism, with MI, and some components of metabolic syndrome (MetS).
|
24695040 |
2014 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
Biomarker
|
disease |
BEFREE |
When stratified according to PAI-1 4G/5G polymorphism, there was no significant difference in all metabolic parameters among PAI-1 genotype groups in patients with HTN as well as subjects with normal blood pressure.
|
22613596 |
2012 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to evaluate the PAI-1 4G/5G polymorphism in women with and without endometrial cancer and to analyze the influence of this polymorphism on PAI-1 expression in endometrial tissue.
|
22055623 |
2012 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the influence of PAI-1 4G/5G polymorphism on plasma PAI-1 levels and its association with CAD assessed by coronary angiography.
|
22011808 |
2011 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate causal relationships for four of the most robust genes associated with stroke while also showing that PAI-1 4G/5G polymorphism influences cardiovascular risk via a mechanism not simply related to plasma levels of PAI-1 (or tPA) alone.
|
20161734 |
2010 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that women carrying a 4G/4G genotype of the PAI-1 gene are not at increased risk for developing HELLP syndrome and are thus in line with the majority of previous studies on the association between the PAI-1 4G/5G polymorphism and pre-eclampsia.
|
18058192 |
2009 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAI-1 4G/5G polymorphism (both on germinal and tumor DNA) and plasma PAI-1 levels were investigated in 99 BC patients and 50 unrelated healthy women similar for age and menopausal status.
|
19351570 |
2009 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAI-1 levels in endometrial tissue and peritoneal fluid seem to be associated with PAI-1 4G/5G polymorphism in controls.
|
18423526 |
2008 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We assessed PAI-1 activity and PAI-1 4G/5G polymorphism in hemodialysis (HD) subjects and any association between thrombotic vascular access (VA) events and PAI-1 polymorphism.
|
18609532 |
2008 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed the influence of the PAI-1 4G/5G polymorphism on tissue PAI-1 levels and its association with tumor severity in women with breast cancer.
|
15907980 |
2006 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PAI-1 4G/5G polymorphism is a major genetic determinant of plasma PAI-1 levels, with 4G/4G homozygotes having elevated PAI-1 levels relative to 5G allele carriers.
|
16855181 |
2006 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Venous blood samples were taken for PAI-1 4G/5G polymorphism and PAI-1 level one week after stroke.
|
15630497 |
2005 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, we explore whether transforming growth factor (TGF-beta1), a key regulator of PAI-1 expression, modifies the influence of the PAI-1 4G/5G polymorphism on these traits.
|
15297806 |
2004 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The induction of increased PAI-1 expression in human arterial smooth muscle cells by growth factors implicated in accelerated atherogenesis is independent of the PAI-1 4G/5G polymorphism.
|
12876623 |
2003 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, this study explores whether a high level of PAI-1 or whether the PAI-1 4G/5G polymorphism synergistically interacts with any established environmental risk factor for MI.
|
12783120 |
2003 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have shown ethnic differences in the PAI-1 4G/5G polymorphism along with corresponding differences in circulating PAI-1 levels.
|
12719278 |
2003 |
|
PAI-1 4G/5G polymorphism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes.
|
10641442 |
1999 |