PRKN, parkin RBR E3 ubiquitin protein ligase, 5071

N. diseases: 409; N. variants: 88
Disease: Herpes Simplex Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.060 Biomarker group BEFREE Infected cell protein 0 (ICP0) of herpes simplex virus 1 (HSV-1) is an immediate early protein containing a RING-type E3 ubiquitin ligase. 29093084 2018
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.060 Biomarker group BEFREE Infected cell protein 0 (ICP0) of herpes simplex virus 1 (HSV-1) is an immediate early protein containing a RING-type E3 ubiquitin ligase. 30451237 2018
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.060 Biomarker group BEFREE Two overlapping regions within the N-terminal half of the herpes simplex virus 1 E3 ubiquitin ligase ICP0 facilitate the degradation and dissociation of PML and dissociation of Sp100 from ND10. 24089549 2013
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.060 Biomarker group BEFREE The herpes simplex virus-1 (HSV-1)-infected cell protein 0 (ICP0) is an E3 ubiquitin ligase implicated in cell cycle arrest and DNA repair inhibition. 18728637 2008
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.060 Biomarker group BEFREE The Herpes simplex virus type-1 (HSV-1) regulatory protein ICP0, a RING-finger E3 ubiquitin ligase, stimulates the onset of viral lytic replication and the reactivation of quiescent viral genomes from latency. 18590780 2008
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.060 GeneticVariation group BEFREE Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity. 14645576 2003