PRKN, parkin RBR E3 ubiquitin protein ligase, 5071

N. diseases: 409; N. variants: 88
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 Biomarker disease BEFREE Cul4 E3 ubiquitin ligase regulates ovarian cancer drug resistance by targeting the antiapoptotic protein BIRC3. 30718461 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 Biomarker disease BEFREE Interaction of E3 Ubiquitin Ligase MARCH7 with Long Noncoding RNA MALAT1 and Autophagy-Related Protein ATG7 Promotes Autophagy and Invasion in Ovarian Cancer. 29794480 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 Biomarker disease BEFREE Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. 25114896 2014
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 AlteredExpression disease BEFREE PARK2 expression was down-regulated in 60.0% of the primary ovarian tumors analyzed. 12874785 2003
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 AlteredExpression disease LHGDN Analysis of Parkin protein expression with antibodies revealed that most of the ovarian cancer cell lines and primary tumors had diminished or absent Parkin expression. 14614460 2003
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 GeneticVariation disease LHGDN Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. 12719539 2003
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 CausalMutation disease CLINVAR
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.460 Biomarker disease CTD_human