Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This work highlights the potential of PAX3-FKHR to functionally operate as a deregulated Pangene and may have implications with regard to the identity of the precursor cell giving rise to alveolar rhabdomyosarcoma.
|
17490646 |
2007 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.
|
21882254 |
2012 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The reciprocal t(2;13)(q36.1;q14.1) in human alveolar rhabdomyosarcoma (A-RMS) creates a pathognomonic PAX3-FOXO1 fusion gene.
|
25659124 |
2015 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A sample from a patient with a diagnosis of embryonal rhabdomyosarcoma on presentation and expression of PAX3-FKHR fusion transcript yielded a small focus of alveolar rhabdomyosarcoma and was reclassified as alveolar rhabdomyosarcoma.
|
10718207 |
2000 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization.
|
7536457 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We have isolated two isoforms of cDNA clones from the human PAX3 gene, a candidate gene responsible for Waardenburg syndrome type I (WSI) as well as a gene associated with development of alveolar rhabdomyosarcoma.
|
7545913 |
1994 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Therapeutic cytodifferentiation in alveolar rhabdomyosarcoma without genetic change of the PAX3-FKHR chimeric fusion gene: a case study.
|
23797277 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The FKHR gene, which contains a forkhead DNA-binding motif, is fused to either PAX3 or PAX7 by the t(2;13) or t(1;13) translocation in alveolar rhabdomyosarcoma,respectively.
|
8634710 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the last intron of PAX3, which contains the previously mapped t(2;13)(q35;q14) translocation breakpoints of alveolar rhabdomyosarcoma, revealed the presence of a pair of inverted Alu repeats and a pair of inverted (GT)n-rich microsatellite repeats within a 5-kb region.
|
7782066 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The presence of PAX3-FOXO1 in SNS and alveolar rhabdomyosarcoma suggests that these two entities are genetically similar lesions arising from distinct progenitor cell pools.
|
26355893 |
2016 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these preclinical studies validate the PLK1-PAX3-FOXO1 axis as a rational target to treat aRMS.
|
25398439 |
2015 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In humans, mutations in the PAX3 gene cause Waardenburg syndrome, whereas a chromosomal translocation that generates a PAX3-FOXO1 fusion gene is associated with the development of alveolar rhabdomyosarcoma.
|
19199574 |
2009 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma.
|
10439042 |
1999 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
|
24334454 |
2014 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma (RMS) is associated with an underlying pathogenic translocation involving either PAX3 or PAX7 and FOXO1.
|
31299267 |
2019 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Both areas showed diffuse nuclear expression for myogenin, and both areas expressed the PAX3-FKHR fusion gene, a genetic change associated with alveolar but not embryonal RMS.
|
19175284 |
2009 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
|
23733015 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Pax3-FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t(2;13) (q35;q14) chromosomal translocation.
|
10393185 |
1999 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
<i>PPP2R1A</i> regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.
|
29861864 |
2018 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.
|
22710718 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this review, we will discuss the current knowledge regarding potential therapeutic targets that might contribute to indirect interference with PAX3-FOXO1 activity in alveolar rhabdomyosarcoma at the different molecular levels and extrapolate these findings to fusion transcription factors in general.
|
29146205 |
2018 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
|
7630639 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to its therapeutic approaches.
|
28883017 |
2017 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
|
12039929 |
2002 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
With the difficulties in morphological diagnosis of alveolar rhabdomyosarcoma on increasingly used small needle biopsy specimens, these data suggest that molecular analysis for PAX3-FKHR will be a clinically useful tool in treatment stratification in the future.
|
11556833 |
2001 |