|
Colitis
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
|
Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Colitis remission corresponded to increased levels of FoxP3+RORγt+CD4+ T cells in the colonic lamina propria that were positively correlated with operational taxonomic units (OTUs) in the S24-7 family and negatively correlated with OTUs in the Clostridiales order.
|
27874308 |
2017 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although Foxp3-deficient (Scurfy) mice lacked Treg cells, they contained Triple(hi)-like and Triple(lo)-like CD4(+) T cells zsuper> T cells infiltrated the skin, whereas Scurfy Triple(lo)CD4(+) T cells induced colitis and wasting disease.
|
27478940 |
2016 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
BALB/C mice with 2,4,6-Trinitrobenzenesulfonic acid solution (TNBS)-induced colitis, when treated with resveratrol, show improved clinical outcomes and reduce induction of inflammatory T cells (Th17 and Th1) while increasing CD4+Foxp3+ regulatory T cells (Tregs) and IL-10-producing CD4+ T cells. miR microarray analysis and polymerase chain reaction (PCR) validation from CD4+ T cells show treatment with resveratrol decreases the expression of several miRs (miR-31, Let7a, miR-132) that targets cytokines and transcription factors involved in anti-inflammatory T cell responses (Foxp3 and TGF-β).
|
31730734 |
2020 |
|
Colitis
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
Bifidobacterium longum affects the methylation level of forkhead box P3 promoter in 2, 4, 6-trinitrobenzenesulphonic acid induced colitis in rats.
|
28733028 |
2017 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis.
|
17056509 |
2006 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
D- mice with fewer RORγt/FoxP3+ T reg cells were significantly more susceptible to colitis than D+ mice.
|
31417552 |
2019 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
For the patients with RD without anti-inflammatory optimization, those with mutant XIAP and FOXP3 died of Crohn's-like colitis and electrolyte exhaustion in awaiting transplantation, while transplantation cured the STAT1 patient.
|
28623282 |
2017 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, all of them induced the Foxp3 and Treg production and ameliorated the TNBS-induced colitis.
|
23643066 |
2013 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL2) of canonical Foxp3-responsive genes, exhibited an increased capacity to suppress conventional T cell proliferation in vitro, and were highly effective at ameliorating colitis in an in vivo model of inflammatory bowel disease.
|
23853094 |
2013 |
|
Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Importantly, stimulation of T cells by Cd44v7-deficient macrophages induced upregulation of Foxp3 in vitro, while cotransfer of Cd44<sup>WT</sup> macrophages into Cd44v7-deficient mice reduced Foxp3<sup>+</sup> T-cell counts and caused colitis.
|
29186109 |
2018 |
|
Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, aloperine regulated T-cell proportions and promoted Foxp3 expression in the spleens and mesenteric lymph nodes of DSS-induced colitis mice and in the spleens of the <i>Foxp3</i><sup>GFP</sup> mice.
|
29056830 |
2017 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In co-housed mice the acquisition of Rickenellaceae by Nod2+/+ mice was associated with increased CD4+ LAP+ Foxp3- proportion and less severe colitis.
|
30250234 |
2018 |
|
Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Oral administration of madecassic acid decreased the percentage of Th17 cells and downregulated the expression of RORγt, IL-17A, IL-17F, IL-21 and IL-22 and increased the percentage of Treg cells and the expression of Foxp3 and IL-10 in the colons of mice with colitis, but it did not affect Th1 and Th2 cells.
|
28358365 |
2017 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Resistance to colitis was associated with an accumulation of hIL-10-expressing CD4(+)Foxp3(+) regulatory T cells specifically within the lamina propria but not other secondary lymphoid tissues.
|
22753934 |
2012 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Systemic delivery of HHph-1 Foxp3 remarkably inhibited the autoimmune symptoms of scurfy mice and the development of colitis induced by scurfy or wild-type CD4 T cells.
|
20937878 |
2010 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The influence of Foxp3+ Treg on intestinal inflammation was tested using the CD4+ T-cell transfer colitis model in Rag-/- C57BL/6 mice and the acute DSS-colitis model.
|
22849659 |
2012 |
|
Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Transfer of CD101(-/-) T cells caused more severe colitis and was associated with an expansion of IL-17-producing T cells and an enhanced expression of IL-2Rα/β independently of FoxP3.
|
26813346 |
2016 |
|
Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that CD8<sup>+</sup>CD103<sup>+</sup> Treg induced <i>ex vivo</i> with TGF-β1 and IL-2 (CD8<sup>+</sup>CD103<sup>+</sup> iTreg), regardless of Foxp3 expression, displayed potent immunosuppressive effect on Th cell response and had therapeutic effect on Th cell-mediated colitis.
|
29441062 |
2018 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
We used the C/EBPβ-/- mice in the CD45RBHigh adoptive transfer model, to assess C/EBPβ-/- CD4+ T cells for their colitiogenic potential, and C/EBPβ-/- CD4+ Foxp3+ Tregs for their ability to inhibit colitis.
|
30085016 |
2018 |