|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The FOXP3 in ATLLs (41.02 ± 24.2) was more than ACs (1.44 ± 1) (P = 0.007) and HAM/TSP (0.45 ± 0.15) (P = 0.01).
|
30577817 |
2018 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Foxp3 expression was similar in ATL and HAMSS, but significantly higher in HAM-SS than AC-SS (p<0.05). p65 was expressed in LSG MNC nuclei from all SS patients and co-expressed with Foxp3.
|
29600938 |
2018 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the mechanisms of FOXP3 expression and its association with Treg-like characteristics in ATL remain unclear.
|
26681759 |
2016 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tax-specific CTL correlated inversely with FoxP3, an increase in the ratio of CD163+ tumor-associated macrophages was associated with worse clinical prognosis, and ATLL cell lines proliferated significantly following direct co-culture with M2 macrophages.
|
26550829 |
2015 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Foxp3 is expressed in around 80% of ATL cases.
|
24792037 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
"The combination of arsenic, interferon-alpha, and zidovudine restores an ""immunocompetent-like"" cytokine expression profile in patients with adult T-cell leukemia lymphoma."
|
23962110 |
2013 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Approximately 60% of ATL cases indeed harbor leukemic cells that express FoxP3, a key transcription factor for T(reg) cells.
|
21347344 |
2011 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that ATLL is not a tumor of FoxP3(+) regulatory T cells, and that a population of FoxP3(+) cells distinct from ATLL cells has regulatory functions and may impair the cell-mediated immune response to HTLV-1 in patients with ATLL.
|
19544530 |
2009 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Of 169 adult T-cell leukemia/lymphoma cases examined, 60 (36%) showed FOXP3 expression in lymphoma cells.
|
18246047 |
2008 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We describe here different features in Foxp3 expression profile between normal and leukemic CD4(+)CD25(+) T cells, using peripheral blood samples from healthy controls (HCs), human T-cell leukemia virus type-1 (HTLV-1)-infected asymptomatic carriers (ACs), patients with adult T-cell leukemia (ATL), and various hematopoietic cell lines.
|
18510697 |
2008 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Of 169 adult T-cell leukemia/lymphoma cases examined, 60 (36%) showed FOXP3 expression in lymphoma cells.
|
18246047 |
2008 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recent studies demonstrated that FOXP3, which is a master control gene of naturally occurring regulatory T (Treg) cells, is expressed in the tumor cells from a subset of patients with ATLL.
|
17278106 |
2007 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that Foxp3 expression is variable in ATL cases and that Foxp3-high ATL cells, which resemble Treg phenotypically as well as functionally, may be involved in immune suppression in ATL.
|
16867905 |
2006 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, among the ATL cells that strongly expressed Foxp3, those from two of the five patients showed no apparent suppressive activity.
|
16361311 |
2006 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects.
|
15198736 |
2004 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, we also found a high expression of FoxP3 mRNA and protein, a hallmark of regulatory T cells, in ATLL cells, indicating the possibility that ATLL cells originated from regulatory T cells.
|
15569983 |
2004 |