ACOX1, acyl-CoA oxidase 1, 51

N. diseases: 95; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 GeneticVariation disease BEFREE Further, in context of a brief obesogenic diet stress, NAFLD progression associated with Acox1 mutation resulted in significantly accelerated and exacerbated hepatocellular damage via induction of profound histological changes in hepatocytes, hepatic inflammation, and robust upregulation of gene expression associated with HCC development. 29563328 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 AlteredExpression disease BEFREE We show that SIRT5 downregulation is associated with increased succinylation and activity of ACOX1 and oxidative DNA damage response in hepatocellular carcinoma (HCC). 29491006 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 Biomarker disease BEFREE Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1(-/-)) mice manifest hepatic metabolic derangements that lead to the development of steatohepatitis, hepatocellular regeneration, spontaneous peroxisome proliferation, and hepatocellular carcinomas. 21801867 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 GeneticVariation disease BEFREE Phenotyping of Acox1(Lampe1) mutants revealed a progression from hepatosteatosis to steatohepatitis, and ultimately hepatocellular carcinoma. 21760938 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 Biomarker disease CTD_human Gene expression patterns in HCCs from Acox1(-/-) mice and in ciprofibrate-induced HCCs were least similar to those observed in human HCCs. 15565109 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 Biomarker disease BEFREE Gene expression patterns in HCCs from Acox1(-/-) mice and in ciprofibrate-induced HCCs were least similar to those observed in human HCCs. 15565109 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.350 Biomarker disease CTD_human The overall commonality of expression between AOX-/- and ciprofibrate-induced liver tumors but not with DENA-induced tumors strongly implicates the activation of PPARalpha and PPARalpha-regulated genes in liver, including those participating in lipid catabolism, as key factors in the development of HCC in AOX-/- and in ciprofibrate-treated mice. 12771043 2003