Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results reveal a tumor suppressor role of p27 in chronic hepatocyte injury-induced liver tumorigenesis and, at the same time, the need to further study the mechanisms for tumor promotion by p27 inactivation.
|
17434927 |
2007 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that expression levels of SKP2, p27 and phospho-MAPK/ERK1/2 may serve as markers for progression in human cervical carcinoma and may also play roles in cervical carcinoma progression and cervical carcinogenesis.
|
17079005 |
2007 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
cMyc and p27 are key genes implicated in carcinogenesis.
|
17567920 |
2007 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, the p27CK- mouse unveils a dual role for p27 during tumorigenesis: It is a tumor suppressor by virtue of its cyclin-CDK regulatory function, and also an oncogene through a cyclin-CDK-independent function.
|
17626791 |
2007 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These findings indicate an important role of EWS-Fli1 in the prevention of senescence, leading to the unlimited growth and oncogenesis of EFT cells through a decrease in the stability of p27 protein due to increased action of Skp2-mediated 26S proteasome degradation.
|
16424012 |
2006 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The role of the loss of p27 protein expression in the oncogenesis of colorectal cancer is still in debate.
|
17123889 |
2006 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In mouse models of both lung and colon cancer down-regulation of p27 promotes tumorigenesis.
|
16966613 |
2006 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, EBV infection, together with overexpressions of p53, and loss expressions of p16 and p27 proteins are involved in the multistep process of human nasopharyngeal epithelial carcinogenesis.
|
16647958 |
2006 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
This also suggests that loss of p27 expression could be more a consequence of carcinogenesis, while lost p16 expression is a true oncogenic event.
|
15978859 |
2006 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Skp2 overexpression may be involved in carcinogenesis and progression of human gastric carcinoma in vivo, possibly via p27 proteolysis.
|
16425372 |
2005 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Defect of spindle checkpoint gene Mad2 and mutation of p27 gene are involved mainly in colorectal carcinogenesis and associated with prognosis of colorectal cancer.
|
15457580 |
2004 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this review we summarize these and other data addressing the role of p27 in normal mammary epithelium and experimental models of mammary carcinogenesis.
|
15082918 |
2004 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It has been suggested that p27 loss occurs early in the carcinogenesis process, with dysplastic epithelium having decreased expression.
|
12811204 |
2003 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The cyclin-dependent kinase inhibitor p27(Kip1) (p27) plays a pivotal role in controlling cell proliferation during development and tumorigenesis. p27 has been implicated in pituitary tumorigenesis in studies of knockout mice and in analyses of human pituitary tumor samples.
|
12050228 |
2002 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development, and has been implicated in tumorigenesis.
|
14558671 |
2002 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In contrast, absent or low p16, p21, and p27 immunostaining was observed in most HPV-negative cervical adenocarcinomas and might contribute to carcinogenesis in these tumors.
|
11499840 |
2001 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Alternatively, these observations could also suggest that pathways involving other than Akt, p27 and cyclin D1 that lie downstream of PTEN play roles in ovarian carcinogenesis.
|
11395387 |
2001 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our data indicate that p27 may be an important regulator of cellular proliferation in the anterior pituitary, the underexpression of which could play a role in pituitary tumorigenesis.
|
10216521 |
1999 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Loss of p27 has not been significantly correlated with tumor proliferation in a number of studies and may reflect alterations in differentiation and adhesion-dependent growth regulation germane to oncogenesis and tumor progression.
|
10066070 |
1998 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To determine whether p27 alterations may be involved in tumorigenesis, we examined its mutational status in 36 primary breast carcinomas and 9 breast cancer cell lines using PCR-single-strand conformational polymorphism, direct DNA sequencing, and Southern blot analysis.
|
8625318 |
1996 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To elucidate the importance of CDKI genes, including the p18 as well as the p16 and p27 genes in tumorigenesis of neuroblastoma, 25 neuroblastomas were analyzed for deletions by Southern blot analysis and for point mutations by polymerase chain reaction-single strand conformational polymorphism.
|
8630967 |
1996 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To determine the role of p27 in tumorigenesis, we examined its mutational status in 74 non-Hodgkin's lymphomas (NHLs) (52 of B-cell phenotype, 22 of T-cell phenotype), 5 lymphoma cell lines, and 42 adult T-cell leukemias/lymphomas (ATLs) using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and Southern blot analyses.
|
7655021 |
1995 |