|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
S100A4, in a reciprocal manner, activates geminin-overexpressing cells to secrete CCL2 that recruits M0-macrophages from the stroma into the tumor.
|
31844158 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There was an association between expression of MCM2, Ki67, and geminin and tumour histologic and invasive front grade (P < 0.05).
|
29745471 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show here that mice lacking geminin develop a significantly higher number of tumors and bear a larger tumor burden than sham-treated controls in urethane-induced lung and azoxymethane/dextran sodium sulfate-induced colon carcinogenesis.
|
29952003 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Twenty of 23 (87.0%) breast cancers with tumor size >2cm and geminin-high showed SUVmax-high, while only 6 of 49 (12.2%) breast cancers ≤2cm in size and with low geminin levels were SUVmax-high.
|
28886153 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the oncogenic activity of these genes (excluding FAM82B) was highly correlated with gene-copy numbers in tumor samples (correlation coefficient, r>0.423), indicating that amplifications of CENPF, GMNN, and CDK13 genes are tightly linked and coincident in tumors.
|
22912832 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Geminin overexpression induces mammary tumors via suppressing cytokinesis.
|
22184288 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Three unique cell-cycle phenotypes were identified: (1) well-differentiated tumours composed predominantly of Mcm2-negative cells, indicative of an out-of-cycle state (18% of cases); (2) high Mcm2-expressing tumours but with low geminin, Aurora A, Plk1 and H3S10ph levels (S-G2-M progression markers), indicative of a G1-delayed/arrested state (24% cases); and (3) high Mcm2-expressing tumours and also expressing high levels of the S-G2-M progression markers, indicative of accelerated cell-cycle progression (58% of cases).
|
19240714 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased Ki67, Mcm2, and geminin levels were each significantly associated with arrested tumor differentiation (P < 0.0001) and aneuploidy (P < or = 0.01).
|
19920109 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ki67, Mcm2, geminin, and Aurora A and B are significantly associated with tumor grade and ploidy status (P < 0.0001).
|
17947481 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In breast cancers, increasing tumour grade is associated with increased Ki67, Mcm2 and geminin expression.
|
16278669 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, the high-growth fraction lymphomas DLBCL and Burkitt lymphoma exhibit differential expression of geminin, with the geminin/Ki67 ratio increasing for more aggressive neoplasms in keeping with a shortened G1 phase and thus representing an important discriminator for differential diagnosis.
|
15682442 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, geminin is now regarded as an oncogene but its role in tumor development remains unknown.
|
15389519 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells.
|
14712211 |
2004 |