|
Steatohepatitis
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
The new transgenic strain of SHR overexpressing a dominant-positive form of human SREBP-1a under control of the phosphoenolpyruvate carboxykinase (PEPCK) promoter exhibited marked hepatic steatosis with major biochemical features of the metabolic syndrome, including hyperglycemia, hyperinsulinemia, and hypertriglyceridemia.
|
15809359 |
2005 |
|
Fatty Liver
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
The new transgenic strain of SHR overexpressing a dominant-positive form of human SREBP-1a under control of the phosphoenolpyruvate carboxykinase (PEPCK) promoter exhibited marked hepatic steatosis with major biochemical features of the metabolic syndrome, including hyperglycemia, hyperinsulinemia, and hypertriglyceridemia.
|
15809359 |
2005 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The present data suggest that, in a German Caucasian population, the -232C/G polymorphism of the PEPCK gene is not associated with Type 2 diabetes.
|
16620271 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This result suggests that mutations in cis-acting PEPCK gene regulatory elements do not constitute a common cause of noninsulin-dependent diabetes mellitus.
|
8636258 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, the single-base variant at position - 232 of the PEPCK gene promoter is most probably not a major contributor to the pathogenesis of type 2 diabetes.
|
12916001 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In this study, we generated transgenic dogs expressing the phosphoenolpyruvate carboxykinase (PEPCK) gene, which is closely involved in the pathogenesis of type 2 diabetes mellitus.
|
22580743 |
2012 |
|
Diabetes
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that mutations of the PEPCK gene promoter contribute to the increased hepatic glucose production that leads to diabetes, we screened for polymorphisms of the PEPCK promoter region in 252 Japanese type 2 diabetic patients and 188 non-diabetic control subjects.
|
12916001 |
2003 |
|
Diabetes Mellitus
|
0.050 |
GeneticVariation
|
group |
BEFREE |
To test the hypothesis that mutations of the PEPCK gene promoter contribute to the increased hepatic glucose production that leads to diabetes, we screened for polymorphisms of the PEPCK promoter region in 252 Japanese type 2 diabetic patients and 188 non-diabetic control subjects.
|
12916001 |
2003 |
|
Hyperglycemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The new transgenic strain of SHR overexpressing a dominant-positive form of human SREBP-1a under control of the phosphoenolpyruvate carboxykinase (PEPCK) promoter exhibited marked hepatic steatosis with major biochemical features of the metabolic syndrome, including hyperglycemia, hyperinsulinemia, and hypertriglyceridemia.
|
15809359 |
2005 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eight of the methylation sites were in genes previously associated with obesity risk (eg, PCK2, CxCl10, BCAT1, HID1, PRDM16, MADD, PXDN, GALE), with several of the findings from the discovery data set replicated in the second cohort.
|
30177354 |
2018 |
|
Anoxemia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Effects of cyclic hypoxia on gene expression and reproduction in a grass shrimp, Palaemonetes pugio.
|
18258771 |
2008 |
|
Anoxia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Effects of cyclic hypoxia on gene expression and reproduction in a grass shrimp, Palaemonetes pugio.
|
18258771 |
2008 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Hypoxia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Effects of cyclic hypoxia on gene expression and reproduction in a grass shrimp, Palaemonetes pugio.
|
18258771 |
2008 |
|
Hypoxemia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Effects of cyclic hypoxia on gene expression and reproduction in a grass shrimp, Palaemonetes pugio.
|
18258771 |
2008 |
|
Phosphoenolpyruvate carboxykinase 2 deficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Endotoxemia
|
0.200 |
Biomarker
|
phenotype |
RGD |
In rat endotoxemia, hepatic PCK2 mRNA and PEPCK-M enzyme activity decreased by 53% and 38%, compared to sham controls.
|
19268478 |
2009 |
|
Steatohepatitis
|
0.120 |
Biomarker
|
disease |
HPO |
|
|
|
|
Fatty Liver
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypoglycemia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Liver Failure
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Impaired gluconeogenesis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Renal steatosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to identify genetic polymorphisms in potential candidate genes for type 2 diabetes by sequencing all exons in the PCK genes (PCK1 and PCK2), and examining the association with type 2 diabetes and diabetic phenotypes in a Korean population (775 type 2 diabetic patients and 316 normal control subjects).
|
16132948 |
2005 |